Protein Info for QEN71_RS04270 in Paraburkholderia sabiae LMG 24235

Annotation: metalloprotease PmbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 PF01523: PmbA_TldD_1st" amino acids 42 to 102 (61 residues), 41.5 bits, see alignment E=1.9e-14 PF19290: PmbA_TldD_2nd" amino acids 129 to 235 (107 residues), 69.7 bits, see alignment E=4.4e-23 PF19289: PmbA_TldD_3rd" amino acids 243 to 455 (213 residues), 238.7 bits, see alignment E=6.4e-75

Best Hits

Swiss-Prot: 37% identical to PMBA_BUCAI: Metalloprotease PmbA homolog (pmbA) from Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)

KEGG orthology group: K03592, PmbA protein (inferred from 98% identity to bph:Bphy_0781)

Predicted SEED Role

"TldE protein, part of TldE/TldD proteolytic complex"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (456 amino acids)

>QEN71_RS04270 metalloprotease PmbA (Paraburkholderia sabiae LMG 24235)
MAADTEARQRFFPHTQDELKEIASDILRHAKSLGASDAATEISEGDGLSVSVRRGEVETI
EHNRDKMVGVTVFIGNKRGNASTSDFSSEALKDTVMAAYNIARFTAEDDCAGLAEAELLE
TDPRDLDLYHPWNLDADEAVELARRAEDAAFATSPQIKNSEGASVSAQHSQFVLGTSRGF
LAGYPYSRHYVACAPIAGSGRNMQRDDWYTSKRSAGELANPEAVGRYAAERALARMGARG
LDTRKVPVLFEAPLAAGLLGAFVQATSGGALYRKTSFLVDSLGKPVFAPHVQVVEDPHVP
RAMGSAPFDEEGVRTKQRSVVKDGVVEGYFLSTYSARKLGMPTTGNAGGSHNLSLRSSLT
QESDDFEEMLRKLGTGLLLTELMGQGVNYVTGDYSRGASGFWVENGKIQYPVEEITVAST
LQEMFRHVVAIGADTIVRGTKQTGSVLIERMTVAGQ