Protein Info for QEN71_RS03915 in Paraburkholderia sabiae LMG 24235

Annotation: xanthine dehydrogenase molybdopterin binding subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02965: xanthine dehydrogenase, molybdopterin binding subunit
  • amino acids 24 to 783 (760 residues), 1256.6 bits, E=0
• PF01315: Ald_Xan_dh_C
  • amino acids 37 to 137 (101 residues), 97.6 bits, E=8.4e-32
• PF02738: MoCoBD_1
  • amino acids 164 to 400 (237 residues), 271.5 bits, E=8e-85
• PF20256: MoCoBD_2
  • amino acids 427 to 711 (285 residues), 321.2 bits, E=1e-99

Best Hits

KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 92% identity to bph:Bphy_0712)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• superpathway of purines degradation in plants (14/18 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (5/7 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (808 amino acids)

>QEN71_RS03915 xanthine dehydrogenase molybdopterin binding subunit (Paraburkholderia sabiae LMG 24235)
MNKQTEAFVHQAERAEADAQTAIGVPLPHESAALHVSGEATYTDDIPELQQTLHAALGLS
RHAHARIVSLDLDAVRAAPGVVAVLTADDIPGENNCGPVLHDDPILADGEVLYLGQPVFI
VVAQSHELARRAAALAKSDDVVRYEPLEAVLTAAEAKAKKQYVLPPLHLKRGAPAEKIAQ
APHRIAGTFEVGGQEQFYLEGQVAYAVPKEMDGMLVYSSTQHPSEMQHVVAHMFGWPTHS
VLCECRRMGGGFGGKESQSALFACAASLAAHKLRRPVKLRADRDDDFMITGKRHDAIYEY
EAGFDDDGRILGARVEIALRAGFSADLSGAVATRAVCHFDNAYYLSDVDIVALPCKTNTQ
SNTAFRGFGGPQGALVMEVMMDGIARELKRDPLDVRRANFYGIGERNVTPYGQTVEDNVI
APLTDELIESSGYLARREAIAAFNATSSVLKRGIAYSPVKFGISFNVPFLNQAGALVHVY
KDGSVLVNHGGTEMGQGLNTKVAQVVAGVFGLPLARVRVTATDTSKVANTSATAASTGSD
LNGKAAEAAATTIRERLASLAAKELGGMPGDVTFAQSEVRANGAAMPFAQLVNAAYLARI
QLWSDGFYATPKVHWDAKTLTGHPFYYFAYGAAVSEVVIDTLTGEWKLVRADVLHDAGQS
INPAIDLGQVEGAFIQGMGWLTTEELWWNRDGRLMTHAPSTYKIPAVSDTPAAFNVKLYS
NDNVEPTVFRSKAVGEPPLLLPFSVFLAIRDAVAATAPEAAHAPPLRAPATPEAILDAID
AMQTLHAGTPSATIDSAASPTSPADTAA