Protein Info for QEN71_RS03300 in Paraburkholderia sabiae LMG 24235

Annotation: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 373 PF00383: dCMP_cyt_deam_1" amino acids 7 to 106 (100 residues), 72.4 bits, see alignment E=3.8e-24 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 10 to 361 (352 residues), 377.1 bits, see alignment E=8.5e-117 PF14437: MafB19-deam" amino acids 29 to 145 (117 residues), 55.5 bits, see alignment E=8.3e-19 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 152 to 365 (214 residues), 185.1 bits, see alignment E=1.3e-58 PF01872: RibD_C" amino acids 153 to 360 (208 residues), 160.5 bits, see alignment E=7.1e-51

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 95% identity to bph:Bphy_0621)

MetaCyc: 68% identical to diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (Burkholderia glumae)
Diaminohydroxyphosphoribosylaminopyrimidine deaminase. [EC: 3.5.4.26]; 5-amino-6-(5-phosphoribosylamino)uracil reductase. [EC: 3.5.4.26, 1.1.1.193]

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (373 amino acids)

>QEN71_RS03300 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD (Paraburkholderia sabiae LMG 24235)
MFSQTDFVHMERALALAWRGLYTTDPNPRVGCVLVKNGEVIGEGYTQPAGHDHAEIQALK
DARKRGHDPKGATAYVTLEPCSHFGRTPPCANALIEAKLSRVVAAMEDPNPRVSGRGLSM
LRDAGIEVRCGLLENDARELNIGFVSRMTRGRPWVRMKVAASLDGRTGLPSGESQWITSE
AARNDGHAWRARASAILTGIGTVKEDNPRMTVRAVDTPRQPHRVLIDSQLEVPPEAQILA
GAPTLIFCSTLTPLLEERAAVLHDRGAEIVPLANENGKVDLPRMLEELSKREVNELHVEA
GYKLNGSLLREGCVDELLVYLAPSLLGNDSMSMFNLAAPGSLDGRTQLEFHAVDRIGDDV
RILARLIRKTPTH