Protein Info for QEN71_RS02080 in Paraburkholderia sabiae LMG 24235

Annotation: formate dehydrogenase accessory sulfurtransferase FdhD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00129: formate dehydrogenase family accessory protein FdhD
  • amino acids 29 to 267 (239 residues), 206.3 bits, E=2.3e-65
• PF02634: FdhD-NarQ
  • amino acids 34 to 270 (237 residues), 229.1 bits, E=3.3e-72

Best Hits

Swiss-Prot: 80% identical to FDHD_BURPS: Sulfur carrier protein FdhD (fdhD) from Burkholderia pseudomallei (strain K96243)

KEGG orthology group: K02379, FdhD protein (inferred from 98% identity to bph:Bphy_0389)

Predicted SEED Role

"Formate dehydrogenase chain D (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• superpathway of C1 compounds oxidation to CO₂ (8/12 steps found)
• oxalate degradation VI (2/4 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• oxalate degradation III (2/5 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Protein Sequence (273 amino acids)

>QEN71_RS02080 formate dehydrogenase accessory sulfurtransferase FdhD (Paraburkholderia sabiae LMG 24235)
MNELDTGEQPGIVEQAVRRHRGGAVESVADHVGQEWPVALVFNGISHAVMMCTPRDLEEF
AVGFAISEGIVERGAHIQDIEVEFRDGKLPHAEVQLTVVQQAFAALKEKRRALSGRTGCG
VCGIESIDLLDLTPERVPDTGFLQRLAPDAIARAAKELPAHQALTKMTGGLHAAAWCDAT
GAIRCAFEDVGRHNALDKLIGRLSLDRVDTREGFVFLSSRASYELVRKAARVDIPMVATI
SAPSSLAITIAREAGVRLVSFCRESSFVDYDTV