Protein Info for QEN71_RS01365 in Paraburkholderia sabiae LMG 24235

Annotation: dicarboxylate/amino acid:cation symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 transmembrane" amino acids 8 to 28 (21 residues), see Phobius details amino acids 42 to 65 (24 residues), see Phobius details amino acids 77 to 99 (23 residues), see Phobius details amino acids 149 to 167 (19 residues), see Phobius details amino acids 181 to 207 (27 residues), see Phobius details amino acids 225 to 247 (23 residues), see Phobius details amino acids 307 to 321 (15 residues), see Phobius details amino acids 347 to 374 (28 residues), see Phobius details amino acids 385 to 401 (17 residues), see Phobius details PF00375: SDF" amino acids 9 to 401 (393 residues), 375 bits, see alignment E=2.3e-116

Best Hits

Swiss-Prot: 98% identical to DCTA_PARP8: C4-dicarboxylate transport protein (dctA) from Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)

KEGG orthology group: K11103, aerobic C4-dicarboxylate transport protein (inferred from 98% identity to bph:Bphy_0225)

MetaCyc: 61% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"Aerobic C4-dicarboxylate transporter for fumarate, L-malate, D-malate, succunate, aspartate"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (426 amino acids)

>QEN71_RS01365 dicarboxylate/amino acid:cation symporter (Paraburkholderia sabiae LMG 24235)
MKKPIYKVLYVQVIVAIIIGIALGHFYPALATDMKPLGDAFIKLIKMVIGPIIFCTVVTG
IAGMEDMKKVGRVGGKALLYFEIVSTFALILGLAATHLLRPGVGFNVDPATLNGKEVASF
AAKAHGQSTVDFLMHIIPDTLVSSFAQGEILQILLIALLFGAVLTHVGERGKPVTSFIES
LSSILFGMVGIITKLAPIGAFGAMAFTIGKYGIGSLIPMLKLIGTFYLTSIVFVVVVLGI
IARMVGFNILRFVAYIKEEMLIVLGTSSSEAALPQLMLKLEKLGCSRSVVGLVVPTGYSF
NLDGTNIYMTMAVLFIAQATNTDLTWGQQLTLLAVTMLTSKGASGVTGAGFITLAATLAV
VPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSAWEKELDRSKLRAALSRDVSV
TETAEV