Protein Info for Psyr_3826 in Pseudomonas syringae pv. syringae B728a ΔmexB

Annotation: Peptidyl-prolyl cis-trans isomerase, cyclophilin type

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 187 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00160: Pro_isomerase" amino acids 28 to 184 (157 residues), 155.1 bits, see alignment E=9.3e-50

Best Hits

Swiss-Prot: 61% identical to PPIA_PSEAE: Peptidyl-prolyl cis-trans isomerase A (ppiA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03767, peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC: 5.2.1.8] (inferred from 100% identity to psb:Psyr_3826)

MetaCyc: 69% identical to peptidyl-prolyl cis-trans isomerase A (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiA precursor (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q4ZPR6 at UniProt or InterPro

Protein Sequence (187 amino acids)

>Psyr_3826 Peptidyl-prolyl cis-trans isomerase, cyclophilin type (Pseudomonas syringae pv. syringae B728a ΔmexB)
MLKKIALAACSVLFAANLMAAPDKATHVVLDTSFGQIEIELADTKAPVSTQNFLGYVDSG
FYTNTIFHRVIPGFMVQGGGFTPQMVQKQTKDPIKNEAQNGLHNVRGTIAMARTSDVNSA
TSQFFINTNDNAMLDNGARDFGYAVFGKVVKGMDVVDNIVNARTTTQKGMQNVPVDPILI
KSAKRVN