Protein Info for PfGW456L13_67 in Pseudomonas fluorescens GW456-L13

Annotation: Cobalamin biosynthesis protein CobG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 423 TIGR02435: precorrin-3B synthase" amino acids 1 to 382 (382 residues), 385.9 bits, see alignment E=1e-119 PF03460: NIR_SIR_ferr" amino acids 12 to 69 (58 residues), 43.4 bits, see alignment E=2.3e-15 amino acids 241 to 306 (66 residues), 65.1 bits, see alignment E=4e-22 PF01077: NIR_SIR" amino acids 78 to 206 (129 residues), 64.7 bits, see alignment E=6.9e-22

Best Hits

KEGG orthology group: K02229, precorrin-3B synthase [EC: 1.14.13.83] (inferred from 74% identity to pba:PSEBR_a616)

Predicted SEED Role

"Cobalamin biosynthesis protein CobG" in subsystem Coenzyme B12 biosynthesis

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.13.83

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QIK0 at UniProt or InterPro

Protein Sequence (423 amino acids)

>PfGW456L13_67 Cobalamin biosynthesis protein CobG (Pseudomonas fluorescens GW456-L13)
LLRVVQALDGGICRIKLDGGAIRAHQAIAVADAAERYASGTIEATNRANLQIRGIGNEQA
ALIDSLLAADLGPRTAAGDDVRNLMLSPGAGIDRRMLFDTRPLAGQILTTLQNHEAFHDL
SAKFAVQLDGGEDLTMLEHPHDLWLSAFEQDGERRLAFGLAGCPTDSPAGSVALADGHAL
VVAVLELFLELARPEQTRMRHLLAEYPIRDIVLRLAERVPLQAVIGWQRVSGASDLHMGA
HPQAESGVVYVGAVPPLGRLDPAMLRGVAQLAREFGDSSLRFTPWQSLLLPNVRTENAAE
VIRQLQCLGLQCEADLPLSRLIACTGSNGCGKSLAETKGDALQLATLLQRHGQTPSVHLS
GCARSCAAAHTAPVTLLAVAHGHYDLYFRDAAQPGFGALHARNLTIEAVAALLDARSRSP
LDA