Protein Info for PfGW456L13_559 in Pseudomonas fluorescens GW456-L13

Annotation: Acetyl-CoA hydrolase (EC 3.1.2.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 497 TIGR03458: succinate CoA transferase" amino acids 13 to 494 (482 residues), 766 bits, see alignment E=7.5e-235 PF02550: AcetylCoA_hydro" amino acids 13 to 215 (203 residues), 102.3 bits, see alignment E=7.6e-33 PF13336: AcetylCoA_hyd_C" amino acids 322 to 463 (142 residues), 138.1 bits, see alignment E=4.9e-44

Best Hits

KEGG orthology group: K01067, acetyl-CoA hydrolase [EC: 3.1.2.1] (inferred from 94% identity to pfo:Pfl01_0111)

Predicted SEED Role

"Acetyl-CoA hydrolase (EC 3.1.2.1)" (EC 3.1.2.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QJY5 at UniProt or InterPro

Protein Sequence (497 amino acids)

>PfGW456L13_559 Acetyl-CoA hydrolase (EC 3.1.2.1) (Pseudomonas fluorescens GW456-L13)
MYRDRIRLPSLLDKVMSAADAAALIEDGMTVGMSGFTRAGEAKAVPQALAERAKVTPLKI
SLMTGASLGNDLDKQLTEAGVLSRRMPFQVDSTLRKAINAGEVMFIDQHLSETVEQLRNQ
QLKLPDIAVIEAVAITEQGHIVPTTSVGNSASFAIFAKHVIVEINMAHNPNLEGLHDIYI
PTYRPTRTPIPLVKVDDRIGSTAIPIPPEKIVAIVVTNQADSPSTVLAPDVETQAIADHL
IDFFKQEVAAGRMTNRLGPLQAGIGTIANSVMCGLIDSPFEDLTMYSEVLQDSTFDLIDA
GKLSFASGSSITLSSRRNADVFGNLERYKDKLVLRPQEISNHPEVVRRLGIIGINTALEF
DIYGNVNSTHVCGTRMMNGIGGSGDFARNAHLSVFVTKSIAKGGAISSVVPMVSHVDHTE
HDVDILVTEVGLADLRGLAPRERARVIIDKCVHPDYHQALNDYFTTACAIGGHTPHILRD
ALSWHINLEETGQMLNK