Protein Info for PfGW456L13_4982 in Pseudomonas fluorescens GW456-L13
Annotation: Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 89% identity to pba:PSEBR_a4716)MetaCyc: 77% identical to 4-aminobutyrate aminotransferase (Pseudomonas putida KT2440)
2-aminoadipate transaminase. [EC: 2.6.1.39]
Predicted SEED Role
"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)
MetaCyc Pathways
- superpathway of L-arginine and L-ornithine degradation (10/13 steps found)
- 4-aminobutanoate degradation I (2/2 steps found)
- 4-aminobutanoate degradation III (2/2 steps found)
- GABA shunt II (3/4 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (8/11 steps found)
- superpathway of 4-aminobutanoate degradation (2/3 steps found)
- 4-aminobutanoate degradation II (1/2 steps found)
- GABA shunt I (2/4 steps found)
- L-lysine degradation II (L-pipecolate pathway) (4/9 steps found)
- L-lysine degradation V (4/9 steps found)
- L-lysine degradation XI (1/5 steps found)
- 4-aminobutanoate degradation V (2/7 steps found)
- L-lysine biosynthesis IV (2/9 steps found)
- L-lysine biosynthesis V (2/10 steps found)
- nicotine degradation I (pyridine pathway) (6/17 steps found)
- superpathway of L-lysine degradation (17/43 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Butanoate metabolism
- Glutamate metabolism
- Lysine biosynthesis
- Lysine degradation
- Propanoate metabolism
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.19
Use Curated BLAST to search for 2.6.1.19 or 2.6.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A293Q6W6 at UniProt or InterPro
Protein Sequence (416 amino acids)
>PfGW456L13_4982 Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19) (Pseudomonas fluorescens GW456-L13) MRSETISQSINIVHPVTLSHGKNAEVWDTDGKRYIDFVGGIGVLNLGHCHPRIVEAIREQ ATRLTHYAFNAAPHEPYLELMDCLSAFMPVGYPVSGMLTNSGAEAAENALKIVRGATGRS AVIAFDGAFHGRTLATLNLNGKVAPYKQKVGVLPGPVFHLPFPSRDNGVTCAEALKAMER LFSVEIDVEDVACFIVEPVQGEAGFLAMDIEFAQALRKFCDDKGIVLIADEIQSGFGRTG ERFAFSRLGIEPDLILLGKSIAGGVPLGAVVGRKSLLDNLPKGGLGGTYSGNPIACAAAL ATLDEMNDANLHAWGTQQEEAIVGRHATWRANNLTPYLGRLTGVGAMRGIELINADGSPA AAQLTQLLALARDAGLLLMPSGKSRHIIRLLAPLTIEAAVLEEGLDILEACLKKLA