Protein Info for PfGW456L13_4917 in Pseudomonas fluorescens GW456-L13

Annotation: Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 178 to 200 (23 residues), see Phobius details PF00512: HisKA" amino acids 266 to 333 (68 residues), 55 bits, see alignment E=6.9e-19 PF02518: HATPase_c" amino acids 383 to 486 (104 residues), 77.6 bits, see alignment E=1e-25

Best Hits

KEGG orthology group: None (inferred from 70% identity to dac:Daci_3072)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QRP3 at UniProt or InterPro

Protein Sequence (506 amino acids)

>PfGW456L13_4917 Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-) (Pseudomonas fluorescens GW456-L13)
MRLTLTQRLSLVFAVLLLVCCGTSAWMQVRSNQMHEQEVVQGLSRDLAQHIARDTVLMDT
QGLMPNAVRDLFSKLMQVNPSVEVYLLDTAGKIVGSAAPEGRIRRERIDLAPIQRLLRGD
ALPILGDDPRSVDARKVFSAAPLKVDGKPAGYLYVVLLGEDHDRLAERGATSAALNTALL
SIGLVALLCLIAGLTAFALITRPLRRLTETVSQFDIDGVPVTPALPVAVEKAASHDEIAV
LDAAFRQMQTRLGEQWRSLTRQDQERRELVANISHDLRTPLASLHGYLETLSLKDATLSP
ADRRRYLGIALDQSRKVGGLAQSLLELVRLEHGFVQPVLERFSLTDLAQDIFQKFELTAE
ARQVELKATFAANVSAACADLGLIERVLTNLFDNALRHTPAGGEVELGLRPQGSFIEVTV
SDTGPGIAPELREGLFLRPFNIGGARRDGGLGLRIVHRILQLHGREIQLIDVPGRGATFR
FSLPIDEETATALAVRSMNLNTPRQA