Protein Info for PfGW456L13_4846 in Pseudomonas fluorescens GW456-L13

Annotation: Cytosol aminopeptidase PepA (EC 3.4.11.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 PF02789: Peptidase_M17_N" amino acids 30 to 158 (129 residues), 119.3 bits, see alignment E=1e-38 PF00883: Peptidase_M17" amino acids 195 to 497 (303 residues), 438.8 bits, see alignment E=1.2e-135

Best Hits

Swiss-Prot: 96% identical to AMPA_PSEPF: Probable cytosol aminopeptidase (pepA) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 96% identity to pfo:Pfl01_0989)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QXI7 at UniProt or InterPro

Protein Sequence (507 amino acids)

>PfGW456L13_4846 Cytosol aminopeptidase PepA (EC 3.4.11.1) (Pseudomonas fluorescens GW456-L13)
MRDNHQFRDPDMELVVKSVNPETLKTATLVVSVGEGRKLGGVAKQLDELSGGAISTVLKR
GDLTGKVGQSLLLHSLPNLKAERVLLVGVGKDDELGDRPFRKIIAGILNTLKSLGGSDAV
LALDEVVVKGRDSYGKTRLLAETLVDGEYSFDQFKSQKAEPRALKKITLLTIKAAQAEVQ
RAVTHATAIANGMAFTRNLGNLPPNICHPTFLGEQAKDLGKEFKDLKVEVLDEKKIKALG
MGSFYAVGQGSAQPPRLIVMQYNGGKKSEKPYALVGKGITFDTGGISLKPGAGMDEMKYD
MGGAASVFGTLRAVLELKLPINLVCILACAENMPSGNASRPGDIVTTMSGQTVEILNTDA
EGRLVLCDALTYSERFKPQAVIDIATLTGACVVALGSHTSGLLGNNDELIGQLLSAGKAA
DDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKNLNWAHLDIAGTAW
TSGGKDKGATGRPVPLLTQYLLDRAKA