Protein Info for PfGW456L13_4223 in Pseudomonas fluorescens GW456-L13

Annotation: Sensory box histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1156 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 39 to 60 (22 residues), see Phobius details amino acids 66 to 87 (22 residues), see Phobius details amino acids 116 to 136 (21 residues), see Phobius details amino acids 161 to 178 (18 residues), see Phobius details amino acids 190 to 216 (27 residues), see Phobius details amino acids 241 to 261 (21 residues), see Phobius details amino acids 282 to 306 (25 residues), see Phobius details amino acids 327 to 354 (28 residues), see Phobius details amino acids 382 to 402 (21 residues), see Phobius details amino acids 411 to 433 (23 residues), see Phobius details amino acids 442 to 467 (26 residues), see Phobius details amino acids 489 to 510 (22 residues), see Phobius details PF12860: PAS_7" amino acids 642 to 756 (115 residues), 150.8 bits, see alignment E=3.2e-48 PF00512: HisKA" amino acids 797 to 863 (67 residues), 49 bits, see alignment 1.1e-16 PF02518: HATPase_c" amino acids 908 to 1016 (109 residues), 82.2 bits, see alignment E=7.4e-27 PF00072: Response_reg" amino acids 1039 to 1149 (111 residues), 41.9 bits, see alignment E=2e-14

Best Hits

KEGG orthology group: None (inferred from 94% identity to pfo:Pfl01_1660)

Predicted SEED Role

"Sensory box histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QUF0 at UniProt or InterPro

Protein Sequence (1156 amino acids)

>PfGW456L13_4223 Sensory box histidine kinase/response regulator (Pseudomonas fluorescens GW456-L13)
MSLSTGLIAVVALAYMAILFAIAFYGDRRSAPLPPRVRAWVYSLSLAVYCTSWTFFGAVG
QAAEQLWSFLPIYLGPILLLVGAPWVLQKMVMISKQENITSIADFIAARYGKSQSLAVVV
ALICLVGVLPYIALQLKGIVLGVNLLIGAGADAMGTRAQDTALIVSLVLALFTIVFGTRN
LDATEHHRGMVLAIAFESLVKLFAFLAVGAFVTYGLYDGFDDLFDQAMLAPRLEQYWKET
INWPSMVVQTGVAMMAIICLPRQFHVTVVENIDPQDLRLAKWVFPAYLALAALFVVPIAL
AGQMMLPSSVLPDSFVISLPLAQAHPALALLAFIGGASAATGMVIVASVALSTMVSNDML
LPWLLRRNNAERPFEVFRQWMLSVRRVSIVVILLLAYVSYRLLGSTASLATIGQIAFAAV
TQLAPAMLGALYWKQANRRGVFAGLAAGTFLWFYTLILPIAALSLGLSLNTFPGLAWLHS
NPLNLPITPLTQGVVLSLAGNFTLFAWVSVLSRTRVSEHWQAGRFIGQEISARPSARSML
AVQINDLLQLAARFVGEERARQSFIRFAYRQGKGFNPNQNADSEWIAHTERLLAGVLGAS
STRAVVKAAIEGREMQLEDVVRIADEASEVLQFNRALLQGAIENITQGISVVDQSLKLVA
WNRRYLELFNYPDGLISIGRPIADIIRYNAERGLCGPGEAEVHVARRLHWMRQGRAHTSE
RMFPNGRVIELIGNPMPGGGFVMSFTDITAFREAEQALTEANEGLEQRVTERTHELSQLN
VALTEAKGTAEAANQSKTRFLAAVSHDLMQPLNAARLFSAALSHQEDGLSGEAQKLVGHL
DSSLRSAEDLISDLLDISRLENGKINPNRQPFALNELFDTLGTEFKVLAREQKLEFRVRT
STLRVDSDIKLLRRILQNFLTNAFRYGKGPVLLGVRRHKEQLCLEVWDRGPGIPEDKLQV
IFEEFKRLDSHQTRAEKGLGLGLAIADGLCRVLGHTLRVRSWPGRGSVFSVSVPLARAQT
AAPVKVAEFNGKLLNGAQVLCIDNEDSILIGMNSLLSRWGCQVWTARNREECAALLGEGM
RPQLALVDYHLDHGETGTDLMAWLRTQMGEPVPGVVISADGRPETVDLVHAAGLDYLAKP
VKPAALRALLSRYIPL