Protein Info for PfGW456L13_3958 in Pseudomonas fluorescens GW456-L13

Annotation: Inner membrane component of tripartite multidrug resistance system

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 516 transmembrane" amino acids 18 to 37 (20 residues), see Phobius details amino acids 58 to 79 (22 residues), see Phobius details amino acids 86 to 105 (20 residues), see Phobius details amino acids 111 to 134 (24 residues), see Phobius details amino acids 146 to 165 (20 residues), see Phobius details amino acids 174 to 194 (21 residues), see Phobius details amino acids 206 to 226 (21 residues), see Phobius details amino acids 238 to 257 (20 residues), see Phobius details amino acids 278 to 299 (22 residues), see Phobius details amino acids 309 to 330 (22 residues), see Phobius details amino acids 341 to 360 (20 residues), see Phobius details amino acids 374 to 397 (24 residues), see Phobius details amino acids 409 to 426 (18 residues), see Phobius details amino acids 485 to 503 (19 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 20 to 494 (475 residues), 395.5 bits, see alignment E=1.8e-122 PF07690: MFS_1" amino acids 24 to 418 (395 residues), 155 bits, see alignment E=1.3e-49

Best Hits

KEGG orthology group: K03446, MFS transporter, DHA2 family, multidrug resistance protein B (inferred from 95% identity to pfo:Pfl01_1876)

Predicted SEED Role

"Inner membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QTT6 at UniProt or InterPro

Protein Sequence (516 amino acids)

>PfGW456L13_3958 Inner membrane component of tripartite multidrug resistance system (Pseudomonas fluorescens GW456-L13)
MAGDQLIRPVGEPTRRDWIAVMSVMLGAFMAVLDIQITNSSLKDIQGALSATLEEGSWIS
TSYLVAEIIMIPLTAWLVQLLSARRLAVWVSLGFLVASLLCSMAWSLESMIVFRALQGFT
GGALIPLAFTLTLIKLPEHHRAKGMAMFAMTATFAPSIGPTLGGWLTENWGWEYIFYINI
PPGLIMIAGLMYGLEKKEAHWELLKSTDYAGILTLGVGLGCLQVFLEEGHRKDWLESSLI
VTLGSIALVSLISFVIVQTSKPNPLINLGILRNRNFGLSSISSVGMGVGLYGSIYLLPLY
LAQIQNYNALQIGEVIMWMGVPQLFLIPLVPKLMKYVSPKWLCTLGFGLFGLASFSSGVL
NPDFAGPQFNQIQIIRALGQPLIMVTISLIATAYILPQDAGSASSLFNILRNLGGAIGIA
LLATLLDARTKVYFDYLRESIVPSNPQVAERIASLADRLGNETAALGKLSEIAHQQASIM
AYNDAFHFVGIALGISMVAVLLTRKLPEGLKAGEAH