Protein Info for PfGW456L13_3647 in Pseudomonas fluorescens GW456-L13

Annotation: D-serine dehydratase transcriptional activator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 330 PF00126: HTH_1" amino acids 27 to 84 (58 residues), 71.1 bits, see alignment E=6.1e-24 PF03466: LysR_substrate" amino acids 108 to 315 (208 residues), 106.5 bits, see alignment E=1.3e-34

Best Hits

Swiss-Prot: 48% identical to DSDC_ECOLI: HTH-type transcriptional regulator DsdC (dsdC) from Escherichia coli (strain K12)

KEGG orthology group: K13636, LysR family transcriptional regulator, D-serine deaminase activator (inferred from 59% identity to ppg:PputGB1_3113)

Predicted SEED Role

"D-serine dehydratase transcriptional activator" in subsystem Glycine and Serine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QXE6 at UniProt or InterPro

Protein Sequence (330 amino acids)

>PfGW456L13_3647 D-serine dehydratase transcriptional activator (Pseudomonas fluorescens GW456-L13)
LGLREKTVVLNLPPRISSRLNSSQFANLHTFLVAARHLSFARAAEELCLTASAVSHRISR
LETALSMKLFQRLTRQVSLTDEGERIFEILQNAMGELSEALEQSTQAEIAGSIALYVRPS
IAQCWLVPRLADFIERYPLVSLDLRVGNDNVDFRTRKIDLALYYANGEFPGLTSHRLMRE
RLAPVCSPEYARRHRLEENPDNLRNCTILHDSLAWDHAAYDAEWTLWAEQHNMLAALPKR
SLTFDRSDLCVTAAMNHAGIAIGRQQLVQKRVDRGELVLPVAEFSRSGHYDYYLVHPSLG
TIPKRLLVFMNWLRECAHQSSPLDENDDLS