Protein Info for PfGW456L13_3336 in Pseudomonas fluorescens GW456-L13
Annotation: Lysine decarboxylase, inducible (EC 4.1.1.18)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01584, arginine decarboxylase [EC: 4.1.1.19] (inferred from 92% identity to pfo:Pfl01_2188)Predicted SEED Role
"Lysine decarboxylase, inducible (EC 4.1.1.18)" in subsystem Lysine degradation (EC 4.1.1.18)
MetaCyc Pathways
- superpathway of arginine and polyamine biosynthesis (16/17 steps found)
- superpathway of polyamine biosynthesis I (7/8 steps found)
- L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
- aminopropylcadaverine biosynthesis (3/3 steps found)
- putrescine biosynthesis II (3/3 steps found)
- L-lysine degradation X (5/6 steps found)
- superpathway of L-arginine and L-ornithine degradation (10/13 steps found)
- L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
- putrescine biosynthesis I (2/2 steps found)
- arginine dependent acid resistance (1/1 steps found)
- cadaverine biosynthesis (1/1 steps found)
- superpathway of polyamine biosynthesis II (6/8 steps found)
- superpathway of putrescine biosynthesis (3/4 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (8/11 steps found)
- spermidine biosynthesis III (2/4 steps found)
- L-lysine degradation I (4/7 steps found)
- bisucaberin biosynthesis (1/5 steps found)
- desferrioxamine B biosynthesis (1/5 steps found)
- desferrioxamine E biosynthesis (1/5 steps found)
- lupanine biosynthesis (1/5 steps found)
- superpathway of L-lysine degradation (17/43 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis II
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Lysine degradation
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.19
Use Curated BLAST to search for 4.1.1.18 or 4.1.1.19
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A293QSE5 at UniProt or InterPro
Protein Sequence (751 amino acids)
>PfGW456L13_3336 Lysine decarboxylase, inducible (EC 4.1.1.18) (Pseudomonas fluorescens GW456-L13) MYKDLKFPVLIVHRDIKADSVAGDRVRGIARELEQEGFSVVSAVDYTEGRLVASTYHGLS CMLIASEDASTHSHLLQNMAELIGLARVRAPDLPIFALGEKVTLENAPADAMAELNQLRG ILYLFEDTVPFLARQVARAARKYLDGLLPPFFKALVQHTADSNYSWHTPGHGGGVAYHKS PVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS TANKIVWHSVVARDDLVLVDRNCHKSVLHSIIMTGAIPLYLCPERNELGIIGPIPLSEFS RESIQAKIDASPLTKGRSPKVKLAVVTNSTYDGLCYNAELIRQQLGNSVEVLHFDEAWYA YAAFHEFFAGRYGMGTSRDEDSPLVFTTHSTHKLLAAFSQASMIHVRDGGARQLDRDRFN EAFMMHISTSPQYGIIASLDVASAMMEGPAGRSLLQEMFDEALSFRRALANLRQHIAADD WWFSIWQPPSAEGIERVVTEDWLLQPDADWHGFGGVTDDYVLLDPIKVTLVMPGLTAGGA LSERGIPAAVVSKFLWERGLVVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDAN VSLASCLPCVAQENVARYQGMGLRDLCDQLHACYRSNATARHLKRMYTVLPEVAMKPADA YDQLVRGEVEAVSIDALDGRIAAVMLVPYPPGIPLIMPGERFTESTRSIIDYLAFARAFD SSFPGFVADVHGLQHEDQGSGRCYTVDCIKE