Protein Info for PfGW456L13_318 in Pseudomonas fluorescens GW456-L13

Annotation: Histidine transport protein (permease)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 transmembrane" amino acids 18 to 38 (21 residues), see Phobius details amino acids 44 to 63 (20 residues), see Phobius details amino acids 89 to 118 (30 residues), see Phobius details amino acids 125 to 143 (19 residues), see Phobius details amino acids 155 to 176 (22 residues), see Phobius details amino acids 200 to 222 (23 residues), see Phobius details amino acids 242 to 262 (21 residues), see Phobius details amino acids 281 to 301 (21 residues), see Phobius details amino acids 332 to 353 (22 residues), see Phobius details amino acids 359 to 381 (23 residues), see Phobius details amino acids 402 to 423 (22 residues), see Phobius details amino acids 429 to 448 (20 residues), see Phobius details PF00324: AA_permease" amino acids 16 to 450 (435 residues), 384.8 bits, see alignment E=5.8e-119 PF13520: AA_permease_2" amino acids 19 to 440 (422 residues), 118.1 bits, see alignment E=5.1e-38

Best Hits

Swiss-Prot: 63% identical to PROY_ECO57: Proline-specific permease ProY (proY) from Escherichia coli O157:H7

KEGG orthology group: K03293, amino acid transporter, AAT family (inferred from 87% identity to pfs:PFLU0368)

MetaCyc: 45% identical to aromatic amino acid:H+ symporter AroP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-56; TRANS-RXN-76; TRANS-RXN-77

Predicted SEED Role

"Histidine transport protein (permease)" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QE03 at UniProt or InterPro

Protein Sequence (468 amino acids)

>PfGW456L13_318 Histidine transport protein (permease) (Pseudomonas fluorescens GW456-L13)
MQQPEKGLKRGLSARHIRFMALGSAIGTGLFYGSASAIQMAGPAVLLAYLIGGAAVFMVM
RALGEMAVHNPVAGSFGQYASTYLGPMAGFILGWTYAFEMVIVGMADVTAFGIYMGFWFP
EVSRWIWVLGVVSIVGGLNLCNVKVFGEMEFWLSLLKVAAIVAMILGGFGIMWFGISSAP
GQATDISNLWSHGGFMPNGMGGLIASFAVVMFAFGGIEIIGVTAGEAKDPQHVLPRAINA
VPLRILLFYVLTMLVLMSIFPWQQIGSQGSPFVQIFDKLGISSAATILNIVVITAAISAI
NSDIFGAGRMMFGLAQQGHAPKGFARLSRNGVPWMTVVVMSAALLLGVLLNYLIPENVFL
LIASVATFATVWVWLMILVTQVAMRRSMSAEQVAQLKFPVPLWPYAPAAAIAFMLFIFGV
LGYFPDTQAALIVGVVWIVLLVLAYLTWVKPAAGQAALVTQDPNFSHR