Protein Info for PfGW456L13_3141 in Pseudomonas fluorescens GW456-L13
Annotation: Aldehyde dehydrogenase (EC 1.2.1.3)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 40% identical to AL1A1_HUMAN: Retinal dehydrogenase 1 (ALDH1A1) from Homo sapiens
KEGG orthology group: K09472, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [EC: 1.2.1.-] (inferred from 91% identity to pba:PSEBR_a3610)MetaCyc: 46% identical to 4-guanidinobutyraldehyde dehydrogenase (Pseudomonas putida)
Gamma-guanidinobutyraldehyde dehydrogenase. [EC: 1.2.1.54]
Predicted SEED Role
"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)
MetaCyc Pathways
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (7/8 steps found)
- L-arginine degradation IX (arginine:pyruvate transaminase pathway) (4/4 steps found)
- superpathway of glycol metabolism and degradation (6/7 steps found)
- ethanol degradation II (3/3 steps found)
- ethanol degradation IV (3/3 steps found)
- superpathway of L-arginine and L-ornithine degradation (10/13 steps found)
- ethylene glycol degradation (2/2 steps found)
- putrescine degradation V (2/2 steps found)
- mitochondrial NADPH production (yeast) (4/5 steps found)
- octane oxidation (4/5 steps found)
- superpathway of ornithine degradation (6/8 steps found)
- L-arginine degradation VIII (arginine oxidase pathway) (3/4 steps found)
- phytol degradation (3/4 steps found)
- putrescine degradation III (3/4 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (8/11 steps found)
- ethanol degradation III (2/3 steps found)
- hypotaurine degradation (2/3 steps found)
- putrescine degradation IV (2/3 steps found)
- putrescine degradation I (1/2 steps found)
- Entner-Doudoroff pathway II (non-phosphorylative) (6/9 steps found)
- D-arabinose degradation II (2/4 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
- fatty acid α-oxidation I (plants) (2/4 steps found)
- serotonin degradation (4/7 steps found)
- histamine degradation (1/3 steps found)
- 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
- noradrenaline and adrenaline degradation (8/13 steps found)
- dopamine degradation (2/5 steps found)
- aromatic biogenic amine degradation (bacteria) (4/8 steps found)
- ceramide degradation by α-oxidation (2/7 steps found)
- sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
- alkane oxidation (1/6 steps found)
- limonene degradation IV (anaerobic) (1/7 steps found)
- ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
- superpathway of pentose and pentitol degradation (13/42 steps found)
KEGG Metabolic Maps
- 1,2-Dichloroethane degradation
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Arginine and proline metabolism
- Ascorbate and aldarate metabolism
- Butanoate metabolism
- Fatty acid metabolism
- Geraniol degradation
- Glycerolipid metabolism
- Glycolysis / Gluconeogenesis
- Histidine metabolism
- Limonene and pinene degradation
- Lysine biosynthesis
- Lysine degradation
- Naphthalene and anthracene degradation
- Propanoate metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.-, 1.2.1.3, 1.2.1.54
Use Curated BLAST to search for 1.2.1.- or 1.2.1.3 or 1.2.1.54
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A293QLV9 at UniProt or InterPro
Protein Sequence (498 amino acids)
>PfGW456L13_3141 Aldehyde dehydrogenase (EC 1.2.1.3) (Pseudomonas fluorescens GW456-L13) MTGLLSAAEYAAIARDLKFPTQSFVNGESYTSVSGNTFTTTNPATNDVLAEITACNAQDV DFAVAKAKEAFEDGRWHKLSPSERKKVLLRFADLLEQNSHELSVLESLDSGKPVRECQLT DVPETIHMIRWHAELIDKIYDSTAPVGPGALSLVVREAIGVVGLVLPWNFPLLMLAWKIG PSLAAGCSIIVKPAKETTLTALRVAELAHEAGVPAGVFNVLSGGGGEVGEPLGRHMDVSM VSFTGSTATGRRFLNYAADSNLKRIVLECGGKNPAVVMNDVEDLDLVASHVVNGAFWNMG ENCSASSRLIVHADIKDELLKRIGVQMREWKMGNPLDPDNRLGAMVSKAHFEKVRSYLEQ AAVEKLDVVYGGNTESDIFVEPTVVDGVGADSRLFQEEIFGPVLAVTTFNTVDEAIALAN DSVYGLAASVYTDNLRNAIKLSREIRAGIVTVNCFGEGDASTPFGGYKESGFGGRDKSIW AHDQYTEIKTIWIDVSER