Protein Info for PfGW456L13_2871 in Pseudomonas fluorescens GW456-L13

Annotation: Histidine kinase/response regulator hybrid protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 845 PF08447: PAS_3" amino acids 200 to 285 (86 residues), 61.8 bits, see alignment E=2.6e-20 TIGR00229: PAS domain S-box protein" amino acids 204 to 299 (96 residues), 33.4 bits, see alignment E=2.1e-12 amino acids 300 to 424 (125 residues), 52 bits, see alignment E=3.7e-18 PF00989: PAS" amino acids 305 to 413 (109 residues), 36.5 bits, see alignment E=1.8e-12 PF08448: PAS_4" amino acids 311 to 418 (108 residues), 64.9 bits, see alignment E=2.9e-21 PF00512: HisKA" amino acids 473 to 538 (66 residues), 36.1 bits, see alignment 2.2e-12 PF02518: HATPase_c" amino acids 581 to 701 (121 residues), 69.5 bits, see alignment E=1.3e-22 PF00072: Response_reg" amino acids 727 to 837 (111 residues), 69 bits, see alignment E=1.6e-22

Best Hits

KEGG orthology group: K00936, [EC: 2.7.3.-] (inferred from 87% identity to pfo:Pfl01_3083)

Predicted SEED Role

"Histidine kinase/response regulator hybrid protein"

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QR83 at UniProt or InterPro

Protein Sequence (845 amino acids)

>PfGW456L13_2871 Histidine kinase/response regulator hybrid protein (Pseudomonas fluorescens GW456-L13)
MNAIPTASDAQALIARIDWASSPLGAASTWPQSLRTAVDIVIHSPMPMLLLWGPQLTQIY
NDGFALLAGSKHPHAFGQPTHLIWPELQDFTDPIYSAVLQGQVRTYSEQRFTLQRGDRES
DFWLDLTYSPIRDEGAQVSGILVTAIETNERRRIALELEQRSAASLKAQRETEERLQLAL
AATDAVGTWDWDISEDRFIADAHFAQLHGIDPAMASQLPISEYLHGVHPEDRALIARSIK
HCITHGTEYAEEYRLLQTDGQMRWVFARGRCYKDHHGRPVRFLGAALDLTERKHTEQALR
QSQTELQLIINAMPVLISYVDREERFRLNNAAYLDWYGLTPQELYGRTILEVLGEEAYAL
RAPHIKEALSGRPCCFSISTPHRDGSIRQALMNYLPRHGADGAVNGFYIFVIDETERKKT
EEALRNLNETLEERVAARTRQLAEANERLQNEMFERERAEDALRHAQKMEAVGQLTGGIA
HDFNNMLTGIIGSLDLMQRYIADGRASEIGRFTEAAVSSANRAAALTHRLLAFSRRQSLN
RKPLNPNELIHSLEDLFRRTKGDHIELNLQLALNIWRVNTDVSQLENALLNLVINARDAM
PDGGELQIETANVFLDGSDMTTLEPVKAGDYVMIAVSDNGTGMTPSVLAKAFDPFFTTKP
IGQGTGLGLSMIYGFAQQSGGHVSLFSLPGRGTSVRLYLPRLHSTESEKVLSPVIGEAPA
AIAGETVMLVEDDAAVRMLVLDLLNELGYRAHEAEDAKGALPLLESDLRVDLLVTDVGLP
GMNGRQLAEIARQHRPELKVLFMTGYAEIAAERQGFLEEGMDMVAKPFSIDLLANKIRTM
ISQPD