Protein Info for PfGW456L13_2743 in Pseudomonas fluorescens GW456-L13

Annotation: Na+ driven multidrug efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 451 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 52 to 75 (24 residues), see Phobius details amino acids 88 to 112 (25 residues), see Phobius details amino acids 132 to 153 (22 residues), see Phobius details amino acids 163 to 185 (23 residues), see Phobius details amino acids 192 to 216 (25 residues), see Phobius details amino acids 243 to 267 (25 residues), see Phobius details amino acids 287 to 309 (23 residues), see Phobius details amino acids 322 to 345 (24 residues), see Phobius details amino acids 361 to 381 (21 residues), see Phobius details amino acids 388 to 408 (21 residues), see Phobius details amino acids 419 to 440 (22 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 19 to 420 (402 residues), 212.1 bits, see alignment E=6.1e-67 PF01554: MatE" amino acids 19 to 178 (160 residues), 95.6 bits, see alignment E=1.3e-31 amino acids 248 to 409 (162 residues), 95.3 bits, see alignment E=1.7e-31

Best Hits

Swiss-Prot: 40% identical to YOEA_BACSU: Probable multidrug resistance protein YoeA (yoeA) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 86% identity to pfo:Pfl01_3541)

Predicted SEED Role

"Na+ driven multidrug efflux pump"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QKR6 at UniProt or InterPro

Protein Sequence (451 amino acids)

>PfGW456L13_2743 Na+ driven multidrug efflux pump (Pseudomonas fluorescens GW456-L13)
MQTQAQRPLWKTYLLFLAPMVLSNFLQSMSGTVNSIYIGQMLGTQALAAVSGMFPIVFFF
IALVIGLGAGAGVLIGQAWGARETHLVKAIAGATLLLGVLIGLVAAVVGSVFARSALVGL
GTPADVLDDAVAYAHVMLWIMPSLLVFVLFTQLLRGVSDTLSPLLALVVSTCVGLALTPA
LIRGWLGFAPMGIQSAAIAGLVGNLVAMGLLAWRLIGKGHPLAPDREFFAAMKLDVAILG
KVLRIGLPTGLQMVVLSLSELVILALVNQHGSQATAAYGAVTQIVNYVQFPALSIAITAS
ILGAQAIGAGRIERIGPILKTGLMINVCLTGGLVVLGYLLSSWLLASFLTEEATLGMAEH
LLHIMLWSLLVFGFQAIIGGIMRASGTVMVPVAISIVCVVGVQLPAAYLLDAKFGLQGVW
MAFPVAYLGMLVLQTLYYKLVWQHQKIERLV