Protein Info for PfGW456L13_2692 in Pseudomonas fluorescens GW456-L13

Annotation: Choline dehydrogenase (EC 1.1.99.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 567 PF00732: GMC_oxred_N" amino acids 11 to 302 (292 residues), 192 bits, see alignment E=1.3e-60 TIGR01810: choline dehydrogenase" amino acids 12 to 538 (527 residues), 778.4 bits, see alignment E=1.8e-238 PF05199: GMC_oxred_C" amino acids 393 to 529 (137 residues), 146.1 bits, see alignment E=1.1e-46

Best Hits

Swiss-Prot: 60% identical to BETA_PHOPR: Oxygen-dependent choline dehydrogenase (betA) from Photobacterium profundum (strain SS9)

KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 82% identity to ppg:PputGB1_3099)

MetaCyc: 50% identical to choline dehydrogenase (Homo sapiens)
Choline dehydrogenase. [EC: 1.1.99.1]

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QSI7 at UniProt or InterPro

Protein Sequence (567 amino acids)

>PfGW456L13_2692 Choline dehydrogenase (EC 1.1.99.1) (Pseudomonas fluorescens GW456-L13)
MTTQKMATQKYDYIIIGAGSAGCVLANRLSEDPATSVLVLEFGGSDKSVVIQMPSAFSIP
MNTKKYNWRYETEPETHLNGRRIHCPRGKVLGGSSSINGLVYIRGHALDFDEWESLGAEG
WGYRNCLPYFKRAESYESGGDSYRGQTGPLHTTNGNHMKNPLYGAWVEAGAEAGYIKTED
CNGYMQEGFGAMHMTVKNGVRCSTANAYLRPAMGRPNLTVITHAMTRQVILEGKRAVGVM
YDHGGQTHQVYCNREVLISSGPIGSPHLLQRSGIGPADVLRKAGIGVRHDLPGVGENLQD
HAEVYIQFGCKEPVTLNSKMDPLSKLMIGLRWLLFKDGLGATNHFEAGGFIRSEKGLRWP
DIQFHFLPAAMRYDGNKPIKGHGFMVLTGPNKPKSRGYVRVRSADPYEHPEIRFNYLERE
EDREGFRRCIRLTREIIGQKAMDRFRDGEIAPGAQVTSDEDLDAFVRDNLESTYHPCGSC
RMGEDEMAVVDSELRVRGIAGLRVIDSSVFPTEPNGNLNAPTIMLAERASDLVRGVQMLP
SADVPVGLVEGWESSQRTSLPGRNVRV