Protein Info for PfGW456L13_2479 in Pseudomonas fluorescens GW456-L13

Annotation: Beta-lactamase (EC 3.5.2.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF00144: Beta-lactamase" amino acids 29 to 377 (349 residues), 275.2 bits, see alignment E=3.9e-86

Best Hits

Swiss-Prot: 69% identical to AMPC_PSEFL: Beta-lactamase (ampC) from Pseudomonas fluorescens

KEGG orthology group: K01467, beta-lactamase [EC: 3.5.2.6] (inferred from 72% identity to pfo:Pfl01_3723)

MetaCyc: 45% identical to beta-lactamase (Escherichia coli K-12 substr. MG1655)
Beta-lactamase. [EC: 3.5.2.6]

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QPQ4 at UniProt or InterPro

Protein Sequence (379 amino acids)

>PfGW456L13_2479 Beta-lactamase (EC 3.5.2.6) (Pseudomonas fluorescens GW456-L13)
MDRLKTIAACMAIFAAAQCVAQDQVETVVNAAVQPVMQAEGIHGMAVAVTVNGQAHYFNY
GVASIETGNPVTQDTLFEIGSVSKTFTATLAAYAQATGKLSLTDKASQVLPALRGSAFDH
ISVLQLGTYSAGGLPLQFPAESDSADKMLGYYKQWKPLYAPGSHRLYSNPSLGLFGYLAA
HSMGQPFDDLMEKTLLPKLGLRHTYVHVPQDQMALYAQGYNKDGKPVRVGPGALDSEAYG
VKTSAADLLSYVGANMKPASLEKPLQQAIALTHSGYYTVGDMTQGLGWEMYRYPITLDRL
LDGNSTPMAMQAHEVQWLNPPQAQPQNVLINKTGSTGGFGAYVAYVPSKDIGIVMLANKN
YPNAQRVRIAHQILSALAR