Protein Info for PfGW456L13_2471 in Pseudomonas fluorescens GW456-L13

Annotation: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00571: CBS
  • amino acids 33 to 79 (47 residues), 37.1 bits, E=1.7e-13
  • amino acids 91 to 143 (53 residues), 53.6 bits, E=1.1e-18

Best Hits

KEGG orthology group: None (inferred from 94% identity to pfo:Pfl01_3735)

Predicted SEED Role

"Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)" in subsystem Purine conversions (EC 1.1.1.205)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• purine nucleotides degradation II (aerobic) (11/11 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• inosine 5'-phosphate degradation (4/4 steps found)
• superpathway of purines degradation in plants (14/18 steps found)
• ureide biosynthesis (6/7 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.205

Use Curated BLAST to search for 1.1.1.205

Sequence Analysis Tools

See A0A293QME5 at UniProt or InterPro

Protein Sequence (162 amino acids)

>PfGW456L13_2471 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (Pseudomonas fluorescens GW456-L13)
LRLRFFKNNDNTRVTTMKTVAQLLKLKDQKNQEVHQIKPDHMVLEALMKMAEKNVGALLV
VENDEVLGIISERDYARKLVLHGRSSVGTPVRDIMVSPVITVDTHQTVDTCLGIMSDRRL
RHLPVVEGGKLIGLLSIGDLVKEAIAEQAELIRQLEQYIRGE