Protein Info for PfGW456L13_229 in Pseudomonas fluorescens GW456-L13

Annotation: Na(+)/H(+) antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 580 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 32 to 54 (23 residues), see Phobius details amino acids 60 to 77 (18 residues), see Phobius details amino acids 88 to 113 (26 residues), see Phobius details amino acids 119 to 142 (24 residues), see Phobius details amino acids 163 to 182 (20 residues), see Phobius details amino acids 191 to 210 (20 residues), see Phobius details amino acids 219 to 236 (18 residues), see Phobius details amino acids 242 to 260 (19 residues), see Phobius details amino acids 272 to 290 (19 residues), see Phobius details amino acids 297 to 322 (26 residues), see Phobius details amino acids 334 to 355 (22 residues), see Phobius details amino acids 362 to 384 (23 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 15 to 387 (373 residues), 198.7 bits, see alignment E=2.2e-62 PF02080: TrkA_C" amino acids 416 to 482 (67 residues), 52.9 bits, see alignment E=4.1e-18 PF03471: CorC_HlyC" amino acids 495 to 568 (74 residues), 44.8 bits, see alignment E=1.5e-15

Best Hits

Swiss-Prot: 97% identical to NHAP2_PSEPF: K(+)/H(+) antiporter NhaP2 (nhaP2) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 97% identity to pfo:Pfl01_0446)

Predicted SEED Role

"Na(+)/H(+) antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QIU9 at UniProt or InterPro

Protein Sequence (580 amino acids)

>PfGW456L13_229 Na(+)/H(+) antiporter (Pseudomonas fluorescens GW456-L13)
LNATTINSLFLIGALLVGASILVSSLSSRLGIPILVIILAVGMAAGVDGAGILFDNYPTA
YLVGNLALAVILLDGGLRTRVSSFRVALWPALSLATVGVLITTGLTGMAAAWLFDLNLIQ
GLLIGAIVGSTDAAAVFSLLGGKGLNERVTASLEIESGSNDPMAVFLTVTLIDMLASGQT
GLHWSLLTHLLREFGIGGVIGLGGGWLMLQLVNRINLATGLYPILVIAGGLVVFALTNAL
HGSGFLAVYICGLVIGNRPVRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLLPIALP
ALALALWMILFARPLSVIVGLLPFKAFHGREKAFISWVGLRGAVPIILAVFPLMAGLPNA
QLYFNLAFFIVLVSLLVQGTSLPWVAKLLKVTVPPEPAPISRSALEVHVTSEWELFVYRL
GAEKWCIGSPLRELNMPEGTRIAALFRGQQLLHPSGSTVLEVDDLLCVIGHEHNLPALGK
LFSQAPQRGLDLRFFGDFVLEGDAQLAAVAALYGLKVEGIDPDMSLGHFIAQKVGGAPVV
GDQVEWNNTIWTVAVMDGNKIGKVGVRFPEGSRPGPGLFL