Protein Info for PfGW456L13_218 in Pseudomonas fluorescens GW456-L13

Annotation: Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 85% identical to MSRA_PSEPW: Peptide methionine sulfoxide reductase MsrA (msrA) from Pseudomonas putida (strain W619)

KEGG orthology group: K07304, peptide-methionine (S)-S-oxide reductase [EC: 1.8.4.11] (inferred from 94% identity to pfo:Pfl01_0459)

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)" (EC 1.8.4.11)

Isozymes

Compare fitness of predicted isozymes for: 1.8.4.11

Use Curated BLAST to search for 1.8.4.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QIT9 at UniProt or InterPro

Protein Sequence (216 amino acids)

>PfGW456L13_218 Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11) (Pseudomonas fluorescens GW456-L13)
MVLRSEILVNKNVLPTKEQALPGRETAMTLPEKHFVFKDTPLLGPFFEDVDFAIFGLGCF
WGAERRFWQREGVVSTVVGYAGGFTPNPTYEEVCSGLTGHAEVVLVVYDKAKVSYEELLA
MFWELHNPTQGMRQGNDIGTQYRSVIYATSPEQLDAALKSKETYQAELSKAGLGEISTEI
DQAPTVYFAETYHQQYLAKNPEGYCGIGGTGVTCPI