Protein Info for PfGW456L13_1959 in Pseudomonas fluorescens GW456-L13

Annotation: DNA-cytosine methyltransferase (EC 2.1.1.37)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 519 PF00145: DNA_methylase" amino acids 116 to 201 (86 residues), 58.3 bits, see alignment E=4.5e-20 amino acids 242 to 512 (271 residues), 86 bits, see alignment E=1.7e-28 TIGR00675: DNA (cytosine-5-)-methyltransferase" amino acids 124 to 512 (389 residues), 119.3 bits, see alignment E=1.4e-38

Best Hits

Predicted SEED Role

"DNA-cytosine methyltransferase (EC 2.1.1.37)" (EC 2.1.1.37)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QNA4 at UniProt or InterPro

Protein Sequence (519 amino acids)

>PfGW456L13_1959 DNA-cytosine methyltransferase (EC 2.1.1.37) (Pseudomonas fluorescens GW456-L13)
MNSSSPIQIVDLFAGPGGLGEGFASFERGTRFNIIVSAEMDPVARKTLRLRAYYRLVKKE
KPEFLEDYYNYCNGISAEPYSNRTKSYWEKSGNEARRITLGDPEDNKILDAIINEKLDRS
KPWILIGGPPCQAYSLVGRSRNMGKVDYRAEDDHRHFLYLEYLRIIQKNKPAVFLMENVK
GILSSKVNGESMFPKILKDLAAPDTALNKSDTGLRYKICSLVEHEDGTHDLIPNEIDPRN
YIIRSEHYGIPQARHRVILLGILVQDNNEPFTFEKLKLEEQVTLDDILKNLPPLRSKLTK
DTDTSDKWCLEILNQIDAIEAPSVARGRSDFVAELRNTRNAVGKYLSTGSLRYEKGIYQG
ITSKPALDDWYIDKNLGVWLNHEARGHMASDLRRYIYASVYAVVNGRAPKGHLEFDLPGL
APDHKNWESGKFCDRFKVQVKNSPSTTITSHISKDGHYFIHPDPTQCRSLTVREAARLQT
FPDNYFFEGNRTQQFHQVGNAVPPMLAAKMAKIVSEIIG