Protein Info for PfGW456L13_1664 in Pseudomonas fluorescens GW456-L13

Annotation: Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1033 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 339 to 357 (19 residues), see Phobius details amino acids 364 to 385 (22 residues), see Phobius details amino acids 391 to 414 (24 residues), see Phobius details amino acids 435 to 455 (21 residues), see Phobius details amino acids 468 to 494 (27 residues), see Phobius details amino acids 528 to 547 (20 residues), see Phobius details amino acids 859 to 877 (19 residues), see Phobius details amino acids 884 to 903 (20 residues), see Phobius details amino acids 909 to 931 (23 residues), see Phobius details amino acids 959 to 978 (20 residues), see Phobius details amino acids 989 to 1014 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 8 to 1014 (1007 residues), 985.7 bits, see alignment E=3.9e-300 PF03176: MMPL" amino acids 299 to 500 (202 residues), 33.4 bits, see alignment E=3.8e-12 PF02355: SecD_SecF_C" amino acids 340 to 493 (154 residues), 20.6 bits, see alignment E=3.9e-08

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 92% identity to pfo:Pfl01_4662)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QHT2 at UniProt or InterPro

Protein Sequence (1033 amino acids)

>PfGW456L13_1664 Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA (Pseudomonas fluorescens GW456-L13)
MKGHGSISAWCIDHPVATVLLTFALVLLGVIAFPRLPVAPLPEAEFPTIQVAAQLPGASP
ETMASSVATPLEVQFSAIPGVTQMTSSSALGSTNLTLQFTLDKSIDTAAQEVQAAINTAA
GKLPKDMPNLPTWRKVNPADSPVLILSVNSSLMPGPELSDLTETLLSRQLSQVDGVGQVV
ITGQQRPAIRVQVSADKLAAIGLTLADIRLAIQQTSLNLAKGALYGESSISTLSTNDQLF
HPDEYSQLIVSYKDGAPVHLKDVAKVVNGSEDAYVQAWAGSQPGVNLVIFRQPGANIVET
VDRIQAALPALQAMLPASVQVKVLIDRTQTIRASLHEVEITLMIAVMLVVAVMALFLRQL
SATLIVSAVLGVSLIASFALMYVMGFSLNNLTLVAIVVAVGFVVDDAIVVVENIHRHLEA
GDGMREAAIKGAGEIGFTVVSISFSLVAAFIPLLFMGGVVGRLFKEFALTATSTIMISVV
VSLTLAPTLAALFMRAPVHHAHDKPGFGERLLAWYEKGLRRALAHQKLMIGVFGLSLGLA
VAGYIFIPKGFFPIQDTGFVLGTTEAAADISYGDMVKKHLVMAEIVAADPAVQAFSHSVG
VSGSNQTIANGRFWIALKKRGDRDVSASEFIDRIRPQLMKVPGIVLYLRAGQDINLSSGP
SRAQYQYVLKSNDGATLSTWTQRLTEKLRSNPAFRDISNDLQLGGSITHISIDRSAAARF
GLTASDVDEALYDAFGQRQVNEFQTQINQYNVILELDTKQRGKAESLNYFYLRSPLSGEM
VPLSALARFDAPTVGPLSIAHDGMFPAANLSFNLAPGVALGDAVIMLNQAKADIGMPTAI
SGNFQGAAQAFQSSLASQPWLILAALLAVYIILGVLYESFVHPLTIISTLPSAGLGAVIM
LWICGQDFSIMALIGLVLLIGIVKKNGILMIDFALEAQRNGGMSPEEAIFKACITRFRPI
IMTTLAALLGALPLMLGYGTGAELRQPLGIAVVGGLLVSQALTLFTTPVIYLWLERLFHR
PKPAPEPVLATTD