Protein Info for PfGW456L13_1383 in Pseudomonas fluorescens GW456-L13

Annotation: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00713: glutamate-1-semialdehyde-2,1-aminomutase
  • amino acids 4 to 424 (421 residues), 635.1 bits, E=2.3e-195
• PF00202: Aminotran_3
  • amino acids 32 to 392 (361 residues), 263 bits, E=2.1e-82

Best Hits

Swiss-Prot: 97% identical to GSA_PSEPF: Glutamate-1-semialdehyde 2,1-aminomutase (hemL) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K01845, glutamate-1-semialdehyde 2,1-aminomutase [EC: 5.4.3.8] (inferred from 97% identity to pfo:Pfl01_4947)

MetaCyc: 66% identical to glutamate-1-semialdehyde 2,1-aminomutase subunit (Salmonella enterica enterica serovar Typhimurium)
Glutamate-1-semialdehyde 2,1-aminomutase. [EC: 5.4.3.8]

Predicted SEED Role

"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (30/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.3.8

Sequence Analysis Tools

See A0A0F4TLF1 at UniProt or InterPro

Protein Sequence (427 amino acids)

>PfGW456L13_1383 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) (Pseudomonas fluorescens GW456-L13)
MSRSETLFANAQKHIPGGVNSPVRAFKSVGGTPLFFKHAEGAYVTDEDDKRYVDYVGSWG
PMILGHSHPDVLDAVRKQLEHGLSYGAPTEMETQMADLVCSLVPSMEMVRMVSSGTEATM
SAIRLARGFTGRDSIIKFEGCYHGHSDSLLVKAGSGALTQGVPSSAGVPAAFAKHTLTLP
FNDIDAVETMLAEVGQDVACIIVEPVAGNMNCVPPAPGFLEGLRTLCDKHGVVLIFDEVM
TGFRVALGGAQAYYGVTPDLTTFGKIIGGGMPVGCFGGKREIMQRIAPLGPVYQAGTLSG
NPLAMAAGLTTLRLISRPGFHAELTDYTTRLLDGLQQRADAAGIPFVTTQAGGMFGLYFS
GADNIVTFDDVMASDAALFGRFFHLMLEGGVYLAPSAFEAGFTSIAHGEAELKLTLDAAE
RAFAALK