Protein Info for PfGW456L13_1313 in Pseudomonas fluorescens GW456-L13

Annotation: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 377 PF00383: dCMP_cyt_deam_1" amino acids 11 to 108 (98 residues), 75.5 bits, see alignment E=4.1e-25 PF14437: MafB19-deam" amino acids 13 to 150 (138 residues), 56.5 bits, see alignment E=4.3e-19 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 15 to 367 (353 residues), 403.3 bits, see alignment E=9.2e-125 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 154 to 368 (215 residues), 174.2 bits, see alignment E=2.8e-55 PF01872: RibD_C" amino acids 155 to 365 (211 residues), 161.6 bits, see alignment E=3.2e-51

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 93% identity to pba:PSEBR_a5040)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A293QJQ8 at UniProt or InterPro

Protein Sequence (377 amino acids)

>PfGW456L13_1313 Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (Pseudomonas fluorescens GW456-L13)
MTTCAEQAILDAHFMARALELARKGHYTTHPNPRVGCVIVQGGQIVGEGWHERAGEPHAE
VHALRAAGEQARGATAYVTLEPCSHHGRTPPCADALVNAGVARVVAAMQDPNPEVAGRGL
QRLTQAGIATESGVLEGEARKLNQGFLKRMEHGLPFVRVKLAMSLDGRTAMESGESQWIT
GPAARSAVQRLRAQASVVLTGADTVLADHARLTVRADELGLDAEQTALVMSRPPLRVLVD
GRLRVPLDAPFFKAGPALVATCVAVEEQYANGPECLIVPGYDGQVDLRQLLVELATRGVN
EVLVEAGPRLAGAFAQLGLVDEFQIFIAGKFLGSSARPLLDWPLAQMKDAPELKITEIRA
VGDDWRVIAIPSPAASV