Protein Info for PfGW456L13_1222 in Pseudomonas fluorescens GW456-L13
Annotation: Indole-3-glycerol phosphate synthase (EC 4.1.1.48)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 95% identical to TRPC_PSEPF: Indole-3-glycerol phosphate synthase (trpC) from Pseudomonas fluorescens (strain Pf0-1)
KEGG orthology group: K01609, indole-3-glycerol phosphate synthase [EC: 4.1.1.48] (inferred from 95% identity to pfo:Pfl01_5113)Predicted SEED Role
"Indole-3-glycerol phosphate synthase (EC 4.1.1.48)" in subsystem Tryptophan synthesis (EC 4.1.1.48)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- L-tryptophan biosynthesis (6/6 steps found)
- superpathway of chorismate metabolism (42/59 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.48
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A293QLN3 at UniProt or InterPro
Protein Sequence (278 amino acids)
>PfGW456L13_1222 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) (Pseudomonas fluorescens GW456-L13) MSVPTVLEKILARKVEEVAERSARVSLAELENLAKAADAPRGFAKALLEQAKKKQPAVIA EIKKASPSKGVIRENFVPADIAKSYEKGGATCLSVLTDIDYFQGADAYLQQARAACNLPV IRKDFMIDPYQIVEARALGADCVLLIVSALDDVKMAELAAVAKSVNLDVLVEVHDGDELE RALKTLDTPLVGVNNRNLHTFDVSLETTLDLLPRIPRDRLVITESGILNRADVELMEISD VYAFLVGEAFMRAESPGTELQRLFFPERGIPVSGSTLD