Protein Info for PP_4730 in Pseudomonas putida KT2440

Annotation: ferric iron uptake global transcriptional repressor Fur-Fe+2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 134 PF01475: FUR" amino acids 9 to 129 (121 residues), 150 bits, see alignment E=1.8e-48

Best Hits

Swiss-Prot: 97% identical to FUR_PSEPU: Ferric uptake regulation protein (fur) from Pseudomonas putida

KEGG orthology group: K03711, Fur family transcriptional regulator, ferric uptake regulator (inferred from 97% identity to ppw:PputW619_0702)

Predicted SEED Role

"Ferric uptake regulation protein FUR" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases or Iron acquisition in Vibrio or Oxidative stress or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88DT9 at UniProt or InterPro

Protein Sequence (134 amino acids)

>PP_4730 ferric iron uptake global transcriptional repressor Fur-Fe+2 (Pseudomonas putida KT2440)
MVENSELRKAGLKVTLPRVKILQMLDSTEQRHMSAEDVYKALMEAGEDVGLATVYRVLTQ
FEAAGLVVRHNFDGGHAVFELADGGHHDHMVNVDTSEVIEFMDAEIEKRQREIVAEHGFE
LVDHNLVLYVRKKK