Protein Info for PP_4622 in Pseudomonas putida KT2440

Annotation: Hmg transcriptional repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 transmembrane" amino acids 141 to 157 (17 residues), see Phobius details PF09339: HTH_IclR" amino acids 17 to 67 (51 residues), 49.4 bits, see alignment 4.7e-17 PF01614: IclR" amino acids 133 to 252 (120 residues), 49.7 bits, see alignment E=5.2e-17

Best Hits

KEGG orthology group: None (inferred from 100% identity to ppu:PP_4622)

Predicted SEED Role

"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88E46 at UniProt or InterPro

Protein Sequence (277 amino acids)

>PP_4622 Hmg transcriptional repressor (Pseudomonas putida KT2440)
MAKASSPTDTGKQKVRSAEVGTDILKALAELSPSTSLSRLAEHVQMPASKVHRYLQALIA
SGFAEQDAATNHYGLGREALRVGLAALGSIDVLKVAAMPLSQLRDELNESCFIAVWGNQG
ATVVSIEPAVRAVTVVTQIGSVLPLLSSSTGLVFAAYLPERETQELRDRELAALQQTASD
YHTLLAGIREKGLHHVHGLLMPGVDALSAPVFNAMGQIAAVMTVVGPTSIFHADEHGPAA
QSLLTAARTVSWRMGYAGNPHCASTSSVSSSTSQSSS