Protein Info for PP_3806 in Pseudomonas putida KT2440

Annotation: Hydrolase, isochorismatase family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00857: Isochorismatase
  • amino acids 9 to 155 (147 residues), 103.6 bits, E=6.9e-34

Best Hits

KEGG orthology group: None (inferred from 100% identity to ppu:PP_3806)

Predicted SEED Role

"Isochorismatase (EC 3.3.2.1)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. (EC 3.3.2.1)

MetaCyc Pathways

• superpathway of chorismate metabolism (42/59 steps found)
• 2,3-dihydroxybenzoate biosynthesis (1/3 steps found)
• enterobactin biosynthesis (4/11 steps found)
• vibriobactin biosynthesis (1/9 steps found)
• bacillibactin biosynthesis (3/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Biosynthesis of siderophore group nonribosomal peptides

Isozymes

Compare fitness of predicted isozymes for: 3.3.2.1

Use Curated BLAST to search for 3.3.2.1

Sequence Analysis Tools

See Q88GB8 at UniProt or InterPro

Protein Sequence (183 amino acids)

>PP_3806 Hydrolase, isochorismatase family (Pseudomonas putida KT2440)
MLIDPLKATLLVVDIQEKLIGAMSDPEGTRARARWLLAATAELALPTVISEQYPKGLGHT
LAELLAVAPAAEVVEKSHFSCVAAECLPASLMAREQVIVCGMETHVCVLQTVLGLLALGK
QVFVVEDACDSRTPASKAAGLARMRAAGAQVVTREMVLFELMGSAGHPQFRHISKTYLIG
EQP