Protein Info for PP_3761 in Pseudomonas putida KT2440

Annotation: Sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1155 transmembrane" amino acids 20 to 42 (23 residues), see Phobius details amino acids 181 to 205 (25 residues), see Phobius details amino acids 261 to 278 (18 residues), see Phobius details PF05227: CHASE3" amino acids 45 to 178 (134 residues), 129.2 bits, see alignment E=3.6e-41 PF13185: GAF_2" amino acids 257 to 388 (132 residues), 50.1 bits, see alignment E=1.2e-16 PF01590: GAF" amino acids 259 to 387 (129 residues), 31.8 bits, see alignment E=6.9e-11 PF00512: HisKA" amino acids 487 to 554 (68 residues), 65.3 bits, see alignment 1.5e-21 PF02518: HATPase_c" amino acids 602 to 711 (110 residues), 98.8 bits, see alignment E=9.2e-32 PF00072: Response_reg" amino acids 765 to 872 (108 residues), 61.2 bits, see alignment E=3.5e-20 amino acids 887 to 969 (83 residues), 53.8 bits, see alignment 7.1e-18 amino acids 1033 to 1145 (113 residues), 103.7 bits, see alignment E=2.3e-33

Best Hits

KEGG orthology group: None (inferred from 100% identity to ppu:PP_3761)

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88GG3 at UniProt or InterPro

Protein Sequence (1155 amino acids)

>PP_3761 Sensor histidine kinase/response regulator (Pseudomonas putida KT2440)
MIQAASMDQRSFRKLLSRNIGLPLGVGLLGAVAFVAVINYLLSAMQWVEHTDRVIGNANE
TVKLSIDMETGMRGFLITGDERFLDPYEVAKPRILGSLKSLRSMVEDNPQQVDRIDRLMA
LQQAWNDFGNEMISLRRSQGDYQASIGNGRGKRITDEIRKEFDDLIITEQQLRMARNEKV
STVTVTAISAFVLFIVGLSALLAYLGRRDLLALSANYAENLQAQQRSAQRLEHQAWLRTG
QTQLAQQVLGQLTLPMLGENILRFFASYLGSVVGAVYVRDEHGRLVRVACYGLSTEEQAR
EQIESDHHGLLAQAVREGRLLRLEELPEDFYRLSSGLGSGLPRSALLMPATEDGQINGVI
ELGFLRPLQERDEELLERVGGNLGMSIESARYRQRLQEVLAETQQLNEELQVQQEELKTA
NEELEEQSRVLKESQAHLETQQAELEQTNEQLSERTEALDRKNDELSQAQLELQARADDL
QRSSKYKSEFLANMSHELRTPLNSSLILAKLLAENAEGNLSEEQVKFAESIYSAGNDLLN
LINDILDIAKVEAGKLEVRPETTQVERLVEGLRGMFQPLAGHKGLAFEVKVEPQVPVTLF
TDRQRLEQILKNLLSNAIKFTERGQVSMNVSFQADSGIVFAVRDTGIGIAADQQQAIFGA
FHQVDGTSNRRYGGTGLGLSISRDLAHLLGGQINVDSSPGQGSVFSLILPERYAAEAEDV
EPQSLRPAVDALPPAPQAPLAAAVTRPAPAFADDRERAPFDTRCILVIEDEPNFARILFD
LAHELGYSCLVAHGADEGFELAAQYIPDAILLDMRLPDHSGLTVLQRLKEQASTRHIPVH
IISVEDRVEAAMHMGAVGYAVKPTSREELKEVFARLEAKLTQKLKHILLVEDDDLQRESI
ARLIGDDDVEITAVAMAQDALALLRQNIYDCMIIDLKLPDMLGNELLKRMTAEDIRAFPP
VIVYTGRNLTREEEADLLKYSRSIIIKGARSPERLLDEVTLFLHKVESQLSNERQRMLKT
ARSRDKVFEGRKVLLVDDDVRNIFALTSALEHKGAIVEIGRNGREAIERLEQHDDIDLVL
MDVMMPEMDGFEATRLIRQQPRWRKLPIIAVTAKAMKDDQQRCLQAGANDYLAKPIDLDR
LFSLIRVWLPQLERI