Protein Info for PP_3372 in Pseudomonas putida KT2440

Annotation: CpxR-Pasp DNA-binding transcriptional two-component system regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 233 PF00072: Response_reg" amino acids 4 to 112 (109 residues), 91.8 bits, see alignment E=3.3e-30

Best Hits

KEGG orthology group: K07662, two-component system, OmpR family, response regulator CpxR (inferred from 100% identity to ppu:PP_3372)

Predicted SEED Role

"Copper-sensing two-component system response regulator CpxR" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88HI5 at UniProt or InterPro

Protein Sequence (233 amino acids)

>PP_3372 CpxR-Pasp DNA-binding transcriptional two-component system regulator (Pseudomonas putida KT2440)
MIPVLLVDDDRELTEMLSLYLAREGFQATAADTGEEGETLALSGHFQVVVLDVMLPGISG
IEVLRRVRARSQVPVLLLTARGDNIDRIAGLELGADDYVPKPSSPGELVARLRAILRRVQ
PYLMGETSAPEVPEQVRSGALKMWPGRREARWGAATLELTGSEFSLLEALARQAGQLVSK
QDLSLNALGRPLTRYDRRIDVHVSSIRQKLGPRADGSSWIQSVRGMGYMLIVE