Protein Info for PP_2120 in Pseudomonas putida KT2440

Annotation: Methyl-accepting chemotaxis protein CtpH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 555 transmembrane" amino acids 25 to 49 (25 residues), see Phobius details amino acids 202 to 224 (23 residues), see Phobius details PF00672: HAMP" amino acids 224 to 265 (42 residues), 33 bits, see alignment 6.2e-12 PF00015: MCPsignal" amino acids 339 to 521 (183 residues), 151.5 bits, see alignment E=2.2e-48

Best Hits

Swiss-Prot: 64% identical to CTPH_PSEAE: Methyl-accepting chemotaxis protein CtpH (ctpH) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03406, methyl-accepting chemotaxis protein (inferred from 100% identity to ppu:PP_2120)

Predicted SEED Role

"Methyl-accepting chemotaxis protein I (serine chemoreceptor protein)" in subsystem Bacterial Chemotaxis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88L17 at UniProt or InterPro

Protein Sequence (555 amino acids)

>PP_2120 Methyl-accepting chemotaxis protein CtpH (Pseudomonas putida KT2440)
MRLYSGLSLLPLVPRPSMLRKSLRVQILSLLGGSVLAMLLIALVCFQFLSSSVRGYAELV
DGPLRASQLIDEANLQFKIQVQEWKNVLLRGRQPAEMDKYWQQFQAREQQVQQLLGQLID
NSDARLKASLQQLRDSHRQLGQAYAQGRQAFLAAGGDPVAGDRAVKGVDRAASEQMSELV
EQLRADARQRAASINASAERTVWLGLLVMLASAVLVGLLSLWLVNRSLIEPIRQLIEYVA
QLSQGSFAARVDSRREDELGRLARAANTLRDFLADTVGRLQDNAQELEGASGQLRSIAGD
MARGTHDQFQRTDQVATAMHEMSATAQEVARHAAEAARAADDADHSAQAGEQVMQQTIDI
IGLVNREIAGTATVIRDLEHDSTRIGKVLEVIRGIAEQTNLLALNAAIEAARAGEAGRGF
AVVADEVRSLAQRTAASIAEIHQIIEAVQSGAVEAVKAIESGQQRSQEGAEQVEQAGQML
QRITQAVEAIRDMNRQIATAAEEQTSVAEDISRNLIEITRIATANQEAVQHTEQAGQRLH
GLSGQLGEVTSRLSA