Protein Info for PP_2110 in Pseudomonas putida KT2440

Annotation: putative ribosomal large subunit pseudouridine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 PF00849: PseudoU_synth_2" amino acids 101 to 248 (148 residues), 101 bits, see alignment E=3.9e-33

Best Hits

KEGG orthology group: None (inferred from 99% identity to ppf:Pput_3629)

Predicted SEED Role

"Similar to ribosomal large subunit pseudouridine synthase A" in subsystem Ribosome biogenesis bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A140FW58 at UniProt or InterPro

Protein Sequence (301 amino acids)

>PP_2110 putative ribosomal large subunit pseudouridine synthase (Pseudomonas putida KT2440)
MNVSSPAMTTPFDPARQQASTVCLPPGNWVTVLDCLCDHFKAIDRAQWLDRFARGRVLDA
KGQAVAADLPYKRGMRLHYFREVPNERPIPVQEVVLHVDEHLVVADKPHFLPVTPTGEYV
EQTLLRRLIRRLDNPHLVPLHRIDRHTAGLVLFSANPHSRSAYQRLFPERRIDKRYQAIA
AAMPQHAFPLVHKSRLVHGEPFFRMHEVEGEANSETLAEVLEKNGERWRYGLSPVTGKTH
QLRVHMAALGAGISNDPFYPQLLNEEDDYQRPLKLLAQSLRFEDPLSGKERYFESRLRLD
W