Protein Info for PP_1875 in Pseudomonas putida KT2440

Annotation: Sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 785 transmembrane" amino acids 29 to 49 (21 residues), see Phobius details amino acids 178 to 206 (29 residues), see Phobius details PF00512: HisKA" amino acids 306 to 370 (65 residues), 70.7 bits, see alignment E=1.3e-23 PF02518: HATPase_c" amino acids 416 to 526 (111 residues), 106 bits, see alignment E=2.3e-34 PF00072: Response_reg" amino acids 666 to 777 (112 residues), 103.2 bits, see alignment E=1.4e-33

Best Hits

KEGG orthology group: None (inferred from 100% identity to ppu:PP_1875)

Predicted SEED Role

"sensor histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88LQ4 at UniProt or InterPro

Protein Sequence (785 amino acids)

>PP_1875 Sensor histidine kinase/response regulator (Pseudomonas putida KT2440)
MLAQRKERETGSGLMDIKFTNRLSYKQARLTVLVGFILGTLLSLIQIGIDYASEDASINR
EVNALLQISHNPASRIAYNIDSELALELTRGLLQSPAVIRARLIDNNETVLADVERPKLQ
DRYRPLSDFLFGEQRQFKERLYLTHMPEQYLGTLYLDIDTFAFGSRFLDRAGITLLNGFA
RSLVLTGLLLALFYMMLTKPLVTVIGALSGSDPRKPRQTRLECPHGHEHDEIGVLVKVAN
QQFVSMATEIEQRRTAENRLTQYLNELEDIVSARTNELKASNSSLSLSNQELEQARSRAL
DMAQARAAFLANMSHEIRTPLNGMLGMIALALDNPLPSEQRQQLAIAHDSGKVLVELLND
ILDLSKFDAGQLELERIAFDMGSMVEDTANLLSQNTAQSVELTCLIASDFPSSVLGDPTR
VRQIVSNLLSNALKFTRFGRVDVRLAAIVGGVRLEVRDTGIGIPEDAQARIFQPFTQAGA
GITRQYGGTGLGLALTRNLCKAMQGHLHIRSEPGFGSCFTAELPLTVHTEAIPPAPLHGR
VAALSAAGSGLNELLQHLLPAWGLTYQRHDSCATLVAAVIDLLITDDVEHLFELRPALKT
PILLVTAYGNFLPNEQSLALAPLHQLARPLARNALYQTLRRTLQGHEPEHPLAIPAITQE
QGRARILLVEDNPVNQLVAKGMLAKLGCQVQLATQGAEALELLAREEFDLVLMDCNMPVM
DGYEASRRIRQSGRWPELPIVALTANAMPEERERCRAAGMNDYLAKPFRREELLALVDHW
VPFSG