Protein Info for PP_1791 in Pseudomonas putida KT2440

Annotation: putative Aldolase/synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00682: HMGL-like
  • amino acids 125 to 249 (125 residues), 87.2 bits, E=7.2e-29

Best Hits

KEGG orthology group: K01666, 4-hydroxy 2-oxovalerate aldolase [EC: 4.1.3.39] (inferred from 100% identity to ppu:PP_1791)

Predicted SEED Role

"4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39)" (EC 4.1.3.39)

MetaCyc Pathways

• 2-hydroxypenta-2,4-dienoate degradation (2/3 steps found)
• catechol degradation I (meta-cleavage pathway) (2/5 steps found)
• mandelate degradation to acetyl-CoA (11/18 steps found)
• catechol degradation II (meta-cleavage pathway) (3/7 steps found)
• meta cleavage pathway of aromatic compounds (5/10 steps found)
• toluene degradation I (aerobic) (via o-cresol) (2/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (2/7 steps found)
• toluene degradation IV (aerobic) (via catechol) (6/13 steps found)
• 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (2/8 steps found)
• p-cumate degradation (2/8 steps found)
• naphthalene degradation to acetyl-CoA (3/12 steps found)
• p-cymene degradation (2/11 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (19/35 steps found)
• L-tryptophan degradation IX (2/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (2/12 steps found)
• superpathway of aerobic toluene degradation (13/30 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (13/42 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Benzoate degradation via hydroxylation
• Biphenyl degradation
• Carbazole degradation
• Ethylbenzene degradation
• Fluorene degradation
• Phenylalanine metabolism
• Styrene degradation
• Toluene and xylene degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.39

Sequence Analysis Tools

See Q88LY5 at UniProt or InterPro

Protein Sequence (534 amino acids)

>PP_1791 putative Aldolase/synthase (Pseudomonas putida KT2440)
MKHLDCTLRDGGYYNNWNFSEALIAQYITAMQAAGIQTIELGLRSLKNSSFSGACAYTTD
AFLSTLDLPPSMTIGVMVNGSELVGKNAGQQALQLLFPSPASESPVDLVRIACHVHEFAE
ALPAASWLKERGYDVGFNLMQIANCSESEIKALAKLANNYPLDVLYFADSMGSMSPDDAA
QIIQWLRSEWQGALGIHTHDNLGLALSNTLRAMDEGVTWVDSTVTGMGRGPGNARTEELA
IEIAARTRKPANLIPLMTLLREHFKPMQVKYGWGTNPYYYLAGKYGIHPTYIQEMLGDSR
FGEEDILAVIEYLRNEGGKKFSVHTLDAARHFYRGAPTGQWAPQDLLAGQDVLLLGTGPG
VAAHRQALEHFIRQHKPVVMALNTQSSIAAELIDVRVACHPVRLLADCEAHIELPQPLIT
PYSMLPMDVQGALANKNVLDFGLNVQPDKFTFEDTHCTIPTSLVVAYAMAAASSGKAKRI
LMAGFDGYPGEDPRNADTNKLFRQYQDTQSSTPLLCLTPTRYDISCQSVYGPLK