Protein Info for PP_1588 in Pseudomonas putida KT2440

Annotation: N-succinyl-L,L-diaminopimelate aminotransferase alternative

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03538: succinyldiaminopimelate transaminase
  • amino acids 1 to 395 (395 residues), 678.7 bits, E=1.2e-208
• PF00155: Aminotran_1_2
  • amino acids 32 to 391 (360 residues), 165.7 bits, E=8.9e-53

Best Hits

KEGG orthology group: K14267, N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.17] (inferred from 100% identity to ppu:PP_1588)

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate aminotransferase alternative (EC 2.6.1.17)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.6.1.17)

MetaCyc Pathways

• aspartate superpathway (22/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.17

Use Curated BLAST to search for 2.6.1.17

Sequence Analysis Tools

See Q88MI3 at UniProt or InterPro

Protein Sequence (398 amino acids)

>PP_1588 N-succinyl-L,L-diaminopimelate aminotransferase alternative (Pseudomonas putida KT2440)
MNHALTQLQPYPFEKLRALLGSVKPAADKRAIALSIGEPKHESPAFVAQAMADNLDKLAV
YPSTLGLPALRQAIGQWCERRFGVPAGWLDADRHILPVNGTREALFAFTQAVVNRADDGL
VISPNPFYQIYEGAALLAGATPHYLPCLENNGFNPDFDAVPAEVWKRCQILFLCSPGNPT
GALVPMNTLKKLIALADEHDFVIAADECYSELYFDEDAPPPGLLSACAELGRSDFARCVV
FHSLSKRSNLPGLRSGFVAGDAQIIKPFLLYRTYHGCAMPVQTQLASIAAWQDEAHVREN
RDQYRAKYDAVLDILQPVLDVQRPDGSFYLWAKVPGDDAEFTRDLFEAQHVTVVPGSYLS
REVDGVNPGAGRVRMALVAPLAECIEAAERIRAFLQNR