Protein Info for PP_0421 in Pseudomonas putida KT2440
Annotation: Anthranilate phosphoribosyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to TRPD_PSEPK: Anthranilate phosphoribosyltransferase (trpD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
KEGG orthology group: K00766, anthranilate phosphoribosyltransferase [EC: 2.4.2.18] (inferred from 99% identity to ppf:Pput_0454)Predicted SEED Role
"Anthranilate phosphoribosyltransferase (EC 2.4.2.18)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 2.4.2.18)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- L-tryptophan biosynthesis (6/6 steps found)
- superpathway of chorismate metabolism (42/59 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.18
Use Curated BLAST to search for 2.4.2.18
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q88QR7 at UniProt or InterPro
Protein Sequence (349 amino acids)
>PP_0421 Anthranilate phosphoribosyltransferase (Pseudomonas putida KT2440) MDIKSALSRIVGQLDLTTEEMREVMRQIMTGQCSEAQIGAFLMGMRMKSESIDEIVGAVS VMRELAEKVELQSLDGVVDIVGTGGDGANIFNVSTASSFVLAAAGCPVAKHGNRAVSGKS GSADLLEAAGIYLNLTPTQVARCIDSLGIGFMFAQSHHSAMKHAAGPRRELGLRTLFNML GPLTNPAGVKHQVVGVFAQTLCRPLAEVLQRLGSKHVLVVHSKDGLDEFSLAAPTFVAEL KNDEITEYWVEPEDLGMKSQSLHGLAVESPQASLELIRDALGRRKTENGQKAAEMIVLNA GAALYAADHAMSLKAGVELAHDVLHTGLAWEKLQELGAFTAVFKVENEA