Protein Info for PP_0106 in Pseudomonas putida KT2440

Annotation: cytochrome c oxidase subunit 3

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 295 transmembrane" amino acids 15 to 34 (20 residues), see Phobius details amino acids 47 to 69 (23 residues), see Phobius details amino acids 89 to 110 (22 residues), see Phobius details amino acids 159 to 179 (21 residues), see Phobius details amino acids 191 to 211 (21 residues), see Phobius details amino acids 231 to 256 (26 residues), see Phobius details amino acids 276 to 294 (19 residues), see Phobius details PF00510: COX3" amino acids 7 to 119 (113 residues), 39.7 bits, see alignment E=2.8e-14 amino acids 154 to 294 (141 residues), 146.4 bits, see alignment E=7.4e-47

Best Hits

KEGG orthology group: K02276, cytochrome c oxidase subunit III [EC: 1.9.3.1] (inferred from 99% identity to ppg:PputGB1_0120)

MetaCyc: 100% identical to cytochrome c oxidase subunit 3 (Pseudomonas putida KT2440)

Predicted SEED Role

"Cytochrome c oxidase polypeptide III (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88RM3 at UniProt or InterPro

Protein Sequence (295 amino acids)

>PP_0106 cytochrome c oxidase subunit 3 (Pseudomonas putida KT2440)
MASHEHYYVPAQSKWPIIATIGMFITVFGLGTWFNDMKAGHPDSHGPLIFFVGALFLAYM
LFGWFGAVVKESRAGLYSPQLDRSFRWGMSWFIFSEVMFFLAFFGALFYVRVLAGPWLGG
EGAKGVTHMLWPTFEFTWPLLHTPDPKLFPPPKEVIDPWHLPLINTILLVSSSVTITIAH
HALRRDHRGPLKFWMALTIVLGISFIALQAFEYYEAYTKLGLTLGSGIYGATFFMLTGFH
GAHVTLGTIILIVMFVRILRGHFNPEKHFGFEAASWYWHFVDVVWVGLFIFVYVL