Protein Info for PFR28_05119 in Pseudomonas sp. RS175

Annotation: DNA mismatch repair protein MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 636 TIGR00585: DNA mismatch repair protein MutL" amino acids 11 to 319 (309 residues), 338.2 bits, see alignment E=3.3e-105 PF02518: HATPase_c" amino acids 30 to 86 (57 residues), 31 bits, see alignment 6.1e-11 PF13589: HATPase_c_3" amino acids 33 to 135 (103 residues), 44.2 bits, see alignment E=4.1e-15 PF01119: DNA_mis_repair" amino acids 222 to 338 (117 residues), 139.6 bits, see alignment E=7.4e-45 PF08676: MutL_C" amino acids 450 to 592 (143 residues), 166.2 bits, see alignment E=7.5e-53

Best Hits

Swiss-Prot: 91% identical to MUTL_PSEFS: DNA mismatch repair protein MutL (mutL) from Pseudomonas fluorescens (strain SBW25)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 96% identity to pba:PSEBR_a539)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (636 amino acids)

>PFR28_05119 DNA mismatch repair protein MutL (Pseudomonas sp. RS175)
MSDEVIGSNARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGARRIDVDVEQGGV
KLLRVRDDGGGIPADDLPLALARHATSKIRDLEDLERVMSLGFRGEALASISSVSRLTLT
SRTRDAEQAWQVETEGRDMASRVQPAAHPVGTSVEVRDLFFNTPARRKFLKAEKTEFDHL
QEVIKRLALARFDVAFHLRHNGKTILSLHEARDDAARARRVAAVCGSGFLEQALPIEVER
NGLHLWGWVGLPTFSRSQADLQYFYVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFVLFF
EVDPSVVDVNVHPTKHEVRFRDGRMVHDFLYGTLHRALGDVRPEDQLAAPATVAGMVRPT
GLEAGEFGPQGEMRLAANTLLEQPQAQPSYTSASSGAGGYQYQYTPRPQSSVPAAEAQAA
YREFFKPLPETGAVALPDGQGDIPPLGYALAQLKGIYILAENAQGLVLVDMHAAHERIMY
ERLKIAMASEGLSGQPLLVPESLAVSQREADCAEEHVGWFQRLGFELQRLGPETLAIRQI
PALLKQAEANRLVSDVLADLMEYGTSDRIQAHLNELLGTMACHGAVRANRRLALPEMNGL
LRDMENTERSGQCNHGRPTWTQLGLDDLDKLFLRGR