Protein Info for PFR28_04962 in Pseudomonas sp. RS175

Annotation: 8-oxoguanine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02022: formiminoglutamate deiminase
  • amino acids 2 to 453 (452 residues), 740.4 bits, E=3.7e-227
• PF01979: Amidohydro_1
  • amino acids 48 to 429 (382 residues), 113.1 bits, E=9e-37

Best Hits

KEGG orthology group: None (inferred from 93% identity to pba:PSEBR_a375)

MetaCyc: 87% identical to formiminoglutamate deiminase subunit (Pseudomonas fluorescens)
Formimidoylglutamate deiminase. [EC: 3.5.3.13]

Predicted SEED Role

"Formiminoglutamic iminohydrolase (EC 3.5.3.13)" in subsystem Histidine Degradation (EC 3.5.3.13)

MetaCyc Pathways

• L-histidine degradation II (5/5 steps found)

KEGG Metabolic Maps

• Histidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.13

Protein Sequence (454 amino acids)

>PFR28_04962 8-oxoguanine deaminase (Pseudomonas sp. RS175)
MPAFFAERALLPSGWANDVRLEVDAAGVLTHVQAGSPADGAERLGGPLLPGMPNLHSHAF
QRAMAGLAEVAGNPNDSFWTWRDLMYRLVGKISPDQLGIIARQLYIEMLKAGYTSVAEFH
YVHHDTDGTPYADPAELALRISHAAQAAGIGLTLLPVLYSHSGFGGQAPNEGQRRFINST
ENYLKLQTRLQPILAAQPTQALGLCFHSLRAVTPGQIQDVLAASDRHCPVHIHIAEQQKE
VDDCLGWSGARPLQWLYENVEVDPRWCLVHATHANADEVALMARSRAIAGLCLTTEANLG
DGIFPAVDFIAQGGRLGIGSDSHVSLSVVEELRWLEYGQRLRDQRRNRLYRPDQPMVGRT
LFDAALEGGAQALGQAVGALDVGKRADWLVLDGNDPYLATARGDGILNRWLFAGGDRQVR
DVMVGGQWVVRDGCHTGEEESARAFAQVLRELLD