Protein Info for PFR28_04755 in Pseudomonas sp. RS175

Annotation: Glutarate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 509 PF00171: Aldedh" amino acids 48 to 504 (457 residues), 584.8 bits, see alignment E=5.4e-180 TIGR01780: succinate-semialdehyde dehydrogenase" amino acids 59 to 503 (445 residues), 770.7 bits, see alignment E=2.4e-236

Best Hits

Swiss-Prot: 90% identical to DAVD_PSEPK: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: None (inferred from 98% identity to pba:PSEBR_a174)

MetaCyc: 97% identical to NAD(P)-dependent succinate-semialdehyde dehydrogenase (Pseudomonas fluorescens)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (509 amino acids)

>PFR28_04755 Glutarate-semialdehyde dehydrogenase (Pseudomonas sp. RS175)
MISLTAAHKAPFYNSNSLRVRAVLLRKADMQLKDTQLFRQQAFIDGAWVDADNGQTIKVT
NPATGEVLGTVPKMGAAETRRAIEAADKALPAWRALTAKERANKLRRWYELLIENQDDLG
RLMTLEQGKPLAEAKGEIVYAASFIEWFAEEAKRIYGDVIPGHQPDKRLIVIKQPIGVTA
AITPWNFPAAMITRKAGPALAAGCTMVIKPASQTPFSALALVELAHRAGIPQGVLSVVTG
SAGDIGGELTSNPIVRKLSFTGSTEIGRQLMAECAKDIKKVSLELGGNAPFIVFDDADLD
KAVEGAIISKYRNNGQTCVCANRLYIQDSVYDAFAEKLKAAVAKLKIGNGLDDGTTTGPL
IDEKAVAKVQEHIADAVGKGATVLAGGKPMQGNFFEPTILTNVPKDAAVAKEETFGPLAP
LFRFKDEAEVIAMSNDTEFGLASYFYARDLGRVFRVAEALEYGMVGVNTGLISNEVAPFG
GIKASGLGREGSKYGIEDYLEIKYLCLGI