Protein Info for PFR28_04595 in Pseudomonas sp. RS175

Annotation: GABA permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 464 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 47 to 65 (19 residues), see Phobius details amino acids 86 to 105 (20 residues), see Phobius details amino acids 124 to 144 (21 residues), see Phobius details amino acids 155 to 178 (24 residues), see Phobius details amino acids 199 to 221 (23 residues), see Phobius details amino acids 241 to 262 (22 residues), see Phobius details amino acids 287 to 308 (22 residues), see Phobius details amino acids 335 to 354 (20 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 401 to 423 (23 residues), see Phobius details amino acids 429 to 448 (20 residues), see Phobius details TIGR01773: GABA permease" amino acids 1 to 451 (451 residues), 743.3 bits, see alignment E=4.5e-228 PF03845: Spore_permease" amino acids 15 to 258 (244 residues), 31.9 bits, see alignment E=9.6e-12 PF00324: AA_permease" amino acids 18 to 426 (409 residues), 418.6 bits, see alignment E=5e-129 PF13520: AA_permease_2" amino acids 19 to 420 (402 residues), 133.9 bits, see alignment E=1.2e-42

Best Hits

Swiss-Prot: 71% identical to BAUD_PSEAE: Probable GABA permease (bauD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03293, amino acid transporter, AAT family (inferred from 96% identity to pba:PSEBR_a6)

MetaCyc: 67% identical to 4-aminobutanoate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-384; TRANS-RXN-57

Predicted SEED Role

"transport permease protein of gamma-aminobutyrate"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (464 amino acids)

>PFR28_04595 GABA permease (Pseudomonas sp. RS175)
MSGTQTSNNLEQGLKPRHVTMLSIAGVIGAGLFVGSGHAIAAAGPAVLLAYAAAGALVVL
VMRMLGEMAVASPDTGSFSTYADRAIGRWAGFTIGWLYWWFWVLVIPLEANAAATILHAW
FPDVAIWAFTLVITLLLTATNLFSVKNYGEFEFWFALVKVVAIIGFIVLGILAISGWLPS
SQVSGVSHLFDTQGFLPNGMGAVLGAILTTMFSFMGTEIVTIAAAESKNPGQQISKATNS
VIWRIGLFYLVSIFIVVALVPWNDPLLASVGSYQTVLERMGIPNAKLIVDIVVLVAVTSC
LNSALYTASRMMFSLGKRGDAPAVSQRTNKSGTPYWAVMLSTAAAFLAVFANYVAPAAVF
EFLLASSGAIALLVYLVIAFSQLRMRKQRMARGEKIAFSMWLFPGLTYLVIVFIIGALTI
MLFQEAHRVEILATGLLSLLVVASGLLVQRRRVGKAGKALQMAN