Protein Info for PFR28_04371 in Pseudomonas sp. RS175

Annotation: Adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 947 PF12633: Adenyl_cycl_N" amino acids 20 to 217 (198 residues), 262.7 bits, see alignment E=2.5e-82 PF01295: Adenylate_cycl" amino acids 245 to 799 (555 residues), 407.4 bits, see alignment E=1.1e-125

Best Hits

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 94% identity to pba:PSEBR_a5482)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (947 amino acids)

>PFR28_04371 Adenylate cyclase (Pseudomonas sp. RS175)
MTRNHEIRPDLDEGIDRKVLSQLRARFLKLNTIRMERALEGLSPRQQSVLTLLPLFFHVN
HPLLPGYVSSTTPAGLSNYEPDASVLTEAQRLTRSFSYKPRHGSNPPRPILGLFLMGSLG
TLAQADQSDMDVWVCHGPDLSDDELAELRKKCQLLEAWAATQGAEAHFFLIDPARFVRGE
RDNQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEEDNYEQYTHTLISKRFI
RADETLDLGHLAYIPPGEFIGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPDVRCLSLR
FKQAVFANRLDLEELDPYMLIYRRIEEYLKARGEPERLELIRRALYLKVNRKLTGPARSS
GWQRTLLERLASEWGWDQRQLALLDSRSQWKVRQVSNERRALVNELTYSYRFLTQFARTE
KTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNKKEPGQNQ
WGLYNGSLNALEWENFAPIKRSRELLELLTWCHRNGVIDSSTRLALHPGESDLSEFELFN
LLGSLQQAIALPLATVDEERLLHASVPSEVLILVNVGIDPLKHHRDLNILMTTERTDSLS
YAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDYLNDLPSGPRQPRLQVRCFC
HNRAQFIARRVEEVIETAQTLLLSNLNHRYLLQVQQHYHVLELVPGQVNHIPLASLSALM
DYLGEELAAYSPLHLDSMALEDHDLALVLPMGQPECIQVFYRVNEDDADLYVLDELNALW
QQRLPYHDEQSLLVPLQRFLQSVLYRRDALLPMDAAQPLNLETLYYQLLPSGNGRARRIE
ARQAPQTPVNKPFYDVQAIIGKAAHGQVHVTLYCNQQEFSELEHGDQLFRVVAGEIVGQR
REAERYRCYITDLDLSGLVGDGACSSNLYLRYKADLERALNEALTLV