Protein Info for PFR28_04218 in Pseudomonas sp. RS175

Annotation: Phosphoribosyl-dephospho-CoA transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 202 TIGR03135: malonate decarboxylase holo-[acyl-carrier-protein] synthase" amino acids 2 to 192 (191 residues), 179.9 bits, see alignment E=2.9e-57 PF20866: MdcG_N" amino acids 2 to 72 (71 residues), 58.8 bits, see alignment E=4.5e-20 PF10620: MdcG" amino acids 79 to 193 (115 residues), 121.7 bits, see alignment E=1.7e-39

Best Hits

Swiss-Prot: 66% identical to MDCG_PSEF5: Phosphoribosyl-dephospho-CoA transferase (mdcG) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

KEGG orthology group: K13934, phosphoribosyl-dephospho-CoA transferase [EC: 2.7.7.66] (inferred from 78% identity to pba:PSEBR_c2g109)

Predicted SEED Role

"Phosphoribosyl-dephospho-CoA transferase (EC 2.7.7.-)" in subsystem Malonate decarboxylase (EC 2.7.7.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.-

Use Curated BLAST to search for 2.7.7.- or 2.7.7.66

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (202 amino acids)

>PFR28_04218 Phosphoribosyl-dephospho-CoA transferase (Pseudomonas sp. RS175)
MAHDLLWGMTPQRLPADAPAWVVEILGLGQPVVVRRATSAAGYVAVGVRGQSREQRYATT
MPVAAIQRRVRPEDLCHIESRRDLPALQALSRLRPLLDASGWTWGIGGSAGFELASGVEA
LHEGSDLDLILRTPSPLDRLRARELLAQLDGSACTVDMQLQTPCGAVALREWAGVSRRVL
LKDDVQARLVSDPWQSTREQVA