Protein Info for PFR28_02745 in Pseudomonas sp. RS175
Annotation: Peptidyl-prolyl cis-trans isomerase cyp18
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 66% identical to PPIB_STRAT: Peptidyl-prolyl cis-trans isomerase cyp18 (cyp18) from Streptomyces antibioticus
KEGG orthology group: K03768, peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC: 5.2.1.8] (inferred from 93% identity to psp:PSPPH_1677)MetaCyc: 63% identical to peptidyl-prolyl cis-trans isomerase B (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]
Predicted SEED Role
"Peptidyl-prolyl cis-trans isomerase PpiB (EC 5.2.1.8)" (EC 5.2.1.8)
Isozymes
Compare fitness of predicted isozymes for: 5.2.1.8
Use Curated BLAST to search for 5.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (167 amino acids)
>PFR28_02745 Peptidyl-prolyl cis-trans isomerase cyp18 (Pseudomonas sp. RS175) MSKVKLTTNHGDIVLQLNAEKAPVTVANFLEYVKAGHYTNTIFHRVIGNFMIQGGGFEPG MKEKKDKRPSIQNEADNGLPNKKYSVAMARTMEPHSASAQFFINVADNSFLNHSAKTVQG WGYAVFGEVIEGTDVVDSIKGVSTTSKAGHQDVPADDVIIEKAEIIE