Protein Info for PFR28_00994 in Pseudomonas sp. RS175

Annotation: Deoxyguanosinetriphosphate triphosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 TIGR01353: putative dGTPase" amino acids 24 to 436 (413 residues), 319.7 bits, see alignment E=2e-99 PF01966: HD" amino acids 61 to 124 (64 residues), 26.5 bits, see alignment E=3.4e-10

Best Hits

Swiss-Prot: 87% identical to DGTL2_PSEAE: Deoxyguanosinetriphosphate triphosphohydrolase-like protein (dgt2) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K01129, dGTPase [EC: 3.1.5.1] (inferred from 98% identity to pba:PSEBR_a1639)

Predicted SEED Role

"Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1)" in subsystem Purine conversions (EC 3.1.5.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (442 amino acids)

>PFR28_00994 Deoxyguanosinetriphosphate triphosphohydrolase (Pseudomonas sp. RS175)
MDWHTLLTRERLGKPLHSPQELGRSPFHKDHDRIIFSGAFRRLGRKTQVHPVSSNDHIHT
RLTHSLEVSCVGRSLGMRVGETIRGALPDWCEPSDLGMVVQSACLAHDIGNPPFGHSGED
AIRYWFQQAAGRGWLDAMSEAERNDFLNFEGNAQGFRVLTQLEYHQFDGGTRLTYATLGT
YLKYPWTARHADSLGYKKHKFGCYQSELPLLEQIAHKLGLPQIEDQRWARHPLVYLMEAA
DDICYALIDLEDGVEMDLLAYSQVESLLLDLVGDDLPETYRQLGPLDSRRRKLAILRGKA
IEHLTNAAARAFVEQQQALLAGTLSGDLVEHMHGPAKRCVLNAKDMARKKIFQDKRKTLN
EIGAYTTLEILLNGFCGAALEQHGGRTPSFKNRRILDLLGNNAPDPNGSLHAAFLRMIDF
IAGMTDSYASEMAQEMTGRIRQ