Protein Info for PFR28_00393 in Pseudomonas sp. RS175

Annotation: LL-diaminopimelate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03538: succinyldiaminopimelate transaminase
  • amino acids 1 to 395 (395 residues), 686.2 bits, E=6.4e-211
• PF00155: Aminotran_1_2
  • amino acids 32 to 391 (360 residues), 169.5 bits, E=6.5e-54

Best Hits

KEGG orthology group: K14267, N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.17] (inferred from 99% identity to pba:PSEBR_a1062)

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate aminotransferase alternative (EC 2.6.1.17)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.6.1.17)

MetaCyc Pathways

• aspartate superpathway (22/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.17

Use Curated BLAST to search for 2.6.1.17

Protein Sequence (399 amino acids)

>PFR28_00393 LL-diaminopimelate aminotransferase (Pseudomonas sp. RS175)
MNNALNQLQPYPFEKLRALLGSVTPNPDKRPIALSIGEPKHRSPSFVAEALASNLEKMAV
YPTTLGIPELREAITGWCERRFNIPNGWLDPARHVLPVNGTREALFAFTQTVVNRGDDAL
VVSPNPFYQIYEGAAFLAGAKPHYLPCLDANGFNPDFDAVSPDIWKRCQILFLCSPGNPT
GALIPVDVLKKLIALADEHDFVIAADECYSELYFDEQSPPPGLLNACVELGRKDFKRCVV
FHSLSKRSNLPGLRSGFVAGDADVLKGFLLYRTYHGCAMPVQTQLASIAAWNDEVHVRAN
RALYREKFDAVLEILSPVLDVQRPDGSFYLWPNVAGDDAAFCRDLFEQEHVTVVPGSYLS
RDVDGVNPGAGRVRMALVAPLAECVEAAERIRAFIQRRG